DTNA, Monoclonal Antibody

Monoclonal DTNA; Anti-DTNA; Dystrobrevin alpha; DRP3; D18S892E; DTN; Dystrophin-related protein 3; Alpha dystrobrevin

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG2a

1C2

Mouse

DTNA antibody was purified by affinity chromatography.

Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.

500 ug-1 mg/ml (lot specific)

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Small volumes of anti-DTNA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Mouse monoclonal DTNA antibody

Cell Biology

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)

FC: 1:100
IF: 1:100
WB: 1:2000

Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant DTNA protein (Right) or empty vector (Left) detected with DTNA antibody

Immunofluorescent staining of COS7 cells transiently transfected with recombinant DTNA protein using DTNA antibody

58,472 Da

dystrobrevin, alpha

dystrobrevin alpha

Dystrobrevin alpha

DRP3; DTN-A  [Similar Products]

DTNA_HUMAN

The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

DTNA: May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. Defects in DTNA are the cause of left ventricular non- compaction type 1 (LVNC1). Left ventricular non- compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected. Belongs to the dystrophin family. Dystrobrevin subfamily. 10 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 18q12

Cellular Component: extrinsic to internal side of plasma membrane; protein complex; axon; cytoplasm; synapse; cell junction; sarcolemma

Molecular Function: protein binding; zinc ion binding; PDZ domain binding

Biological Process: synaptic transmission; striated muscle contraction; neuromuscular synaptic transmission; signal transduction

Disease: Left Ventricular Noncompaction 1

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