Product Name
IRF6, Blocking Peptide
Full Product Name
IRF6 Peptide - middle region
Product Gene Name
IRF6 blocking peptide
[Similar Products]
Product Synonym Gene Name
LPS; OFC6; PIT; PPS; VWS; VWS1[Similar Products]
IRF6 peptide (MBS3229216) is used for blocking the activity of IRF6 antibody (MBS3204249)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O14896
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of IRF6 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IRF6 blocking peptide
This is a synthetic peptide designed for use in combination with anti-IRF6 antibody made
Target Description: IRF6 is a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. Mutations in its gene can cause van der Woude syndrome and popliteal pterygium syndrome. This protein is involved in palate formation.The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. This protein is involved in palate formation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Product Categories/Family for IRF6 blocking peptide
Peptide
Applications Tested/Suitable for IRF6 blocking peptide
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for IRF6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006138
[Other Products]
NCBI GenBank Nucleotide #
NM_006147
[Other Products]
UniProt Primary Accession #
O14896
[Other Products]
UniProt Related Accession #
O14896[Other Products]
NCBI Official Full Name
interferon regulatory factor 6 isoform 1
NCBI Official Synonym Full Names
interferon regulatory factor 6
NCBI Official Symbol
IRF6 [Similar Products]
NCBI Official Synonym Symbols
LPS; PIT; PPS; VWS; OFC6; PPS1; VWS1
[Similar Products]
NCBI Protein Information
interferon regulatory factor 6
UniProt Protein Name
Interferon regulatory factor 6
Protein Family
Interferon regulatory factor
UniProt Gene Name
IRF6 [Similar Products]
UniProt Synonym Gene Names
IRF-6 [Similar Products]
NCBI Summary for IRF6
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]
UniProt Comments for IRF6
Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (). Plays a role in regulating mammary epithelial cell proliferation (). May regulate WDR65 transcription ().
Research Articles on IRF6
1. A; p.Arg9Gln) as a candidate of causative mutation. This mutation was predicted to be deleterious. The codon is conserved in many species. The residue change caused by this mutation would affect the structure of IRF6 to a degree. Our study suggested that the rare IRF6 variant is probably the pathogenic mutation in this family.">We identified a rare mutation in interferon regulatory factor 6 (IRF6) (c.26G>A; p.Arg9Gln) as a candidate of causative mutation. This mutation was predicted to be deleterious. The codon is conserved in many species. The residue change caused by this mutation would affect the structure of IRF6 to a degree. Our study suggested that the rare IRF6 variant is probably the pathogenic mutation in this family.
Precautions
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Disclaimer
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