Full Product Name
CD71 Monoclonal Antibody
Product Synonym Names
CD71; p90; sTfR; T9; TFR; TFR1; TFRC; TR; Transferrin receptor protein 1; TRFR
Product Gene Name
anti-CD71 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P02786
Purity/Purification
Protein A purification
Concentration
1mg/mL (lot specific)
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Immunogen
CD71 fusion protein ag21612
Preparation and Storage
Store at -20 degree C. Avoid freeze/ thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CD71 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD71 antibody
CD71, also known as transferrin receptor protein 1 (TfR1), is a transmembrane glycoprotein composed of two disulfide-linked monomers, each of 90 kDa molecular weight. Each monomer binds one holo-transferrin molecule creating an iron-Tf-TfR complex which enters the cell by endocytosis. CD71 is present on actively proliferating cells and is essential for iron transport into proliferating cells.
Product Categories/Family for anti-CD71 antibody
Stem cells; Cancer
Applications Tested/Suitable for anti-CD71 antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-CD71 antibody
Western Blot: 1:1000-1:10000
Immunohistochemistry: 1:20-1:200
Immunofluoresence: 1:20-1:200
Western Blot (WB) of anti-CD71 antibody
Western Blot analysis of HeLa cells using CD71 Monoclonal Antibody at dilution of 1:2000
NCBI/Uniprot data below describe general gene information for CD71. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001121620.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001128148.2
[Other Products]
UniProt Primary Accession #
P02786
[Other Products]
UniProt Secondary Accession #
Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21; D3DXB0[Other Products]
UniProt Related Accession #
P02786[Other Products]
Molecular Weight
84,871 Da
NCBI Official Full Name
transferrin receptor protein 1 isoform 1
NCBI Official Synonym Full Names
transferrin receptor
NCBI Official Symbol
TFRC [Similar Products]
NCBI Official Synonym Symbols
T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
[Similar Products]
NCBI Protein Information
transferrin receptor protein 1
UniProt Protein Name
Transferrin receptor protein 1
UniProt Synonym Protein Names
T9; p90; CD_antigen: CD71
UniProt Gene Name
TFRC [Similar Products]
UniProt Synonym Gene Names
TR; TfR; TfR1; Trfr; sTfR [Similar Products]
UniProt Entry Name
TFR1_HUMAN
NCBI Summary for CD71
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
UniProt Comments for CD71
TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.
Protein type: Receptor, misc.; Membrane protein, integral; Cell surface
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasmic membrane-bound vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; recycling endosome
Molecular Function: double-stranded RNA binding; glycoprotein binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity
Biological Process: regulation of cell growth; regulation of cell proliferation; transferrin transport
Research Articles on CD71
1. siRNA targeted delivery using transferrin-coupled lipoplexes specifically sensitizes CD71 high expressing malignant cells to antibody-mediated complement attack
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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