Actin-binding Rho-activating protein (ABRA), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of ABRA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS7213771 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Actin-binding Rho-activating protein (ABRA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ABRA. The ELISA analytical biochemical technique of the MBS7213771 kit is based on ABRA antibody-ABRA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ABRA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ABRA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Epigenetics and Nuclear Signaling

43,117 Da

actin-binding Rho activating protein

actin-binding Rho-activating protein; striated muscle activator of Rho-dependent signaling

Actin-binding Rho-activating protein

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ABRA_HUMAN

ABRA: Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.

Protein type: Actin-binding; Transcription, coactivator/corepressor; Contractile

Chromosomal Location of Human Ortholog: 8q23.1

Cellular Component: sarcomere; plasma membrane; actin cytoskeleton

Molecular Function: transcription coactivator activity; actin binding

Biological Process: transcription, DNA-dependent; protein import into nucleus, translocation; positive regulation of Rho protein signal transduction; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity

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