Product Name
ALS2CR8, Polyclonal Antibody
Full Product Name
ALS2CR8 Antibody
Product Synonym Names
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; Calcium-response factor; CaRF; Testis development protein NYD-SP24
Product Gene Name
anti-ALS2CR8 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8N187
Specificity
The antibody detects endogenous levels of total ALS2CR8 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Description
Synthesized peptide derived from internal of human ALS2CR8.
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ALS2CR8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ALS2CR8 antibody
Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence.Hadano S., Nat. Genet. 29:166-173(2001).Tao X., Neuron 33:383-395(2002).Hillier L.W., Nature 434:724-731(2005)
Product Categories/Family for anti-ALS2CR8 antibody
Total protein Ab
Applications Tested/Suitable for anti-ALS2CR8 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ALS2CR8 antibody
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Western Blot (WB) of anti-ALS2CR8 antibody
Western blot analysis of extracts from HuvEc cells, using ALS2CR8 antibody.
Immunohistochemistry (IHC) of anti-ALS2CR8 antibody
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using ALS2CR8 antibody.
NCBI/Uniprot data below describe general gene information for ALS2CR8. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001098056.1
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NCBI GenBank Nucleotide #
NM_001104586.2
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UniProt Primary Accession #
Q8N187
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UniProt Secondary Accession #
Q8ND29; Q8WXC0; Q96J78; Q96Q38; Q96Q39; Q9H712; B4E1W7; G3V1K7[Other Products]
UniProt Related Accession #
Q8N187[Other Products]
Molecular Weight
72,385 Da
NCBI Official Full Name
calcium-responsive transcription factor isoform 1
NCBI Official Synonym Full Names
calcium responsive transcription factor
NCBI Official Symbol
CARF [Similar Products]
NCBI Official Synonym Symbols
ALS2CR8; NYD-SP24
[Similar Products]
NCBI Protein Information
calcium-responsive transcription factor
UniProt Protein Name
Calcium-responsive transcription factor
UniProt Synonym Protein Names
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; Calcium-response factor; CaRF; Testis development protein NYD-SP24
UniProt Gene Name
CARF [Similar Products]
UniProt Synonym Gene Names
ALS2CR8; CaRF [Similar Products]
UniProt Entry Name
CARTF_HUMAN
UniProt Comments for ALS2CR8
CARF: May be a transcription factor. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 2q33.2
Cellular Component: nucleoplasm; nucleolus; nucleus
Molecular Function: DNA binding; transcription factor activity
Biological Process: transcription, DNA-dependent
Research Articles on ALS2CR8
1. Cloned as a calcium- and neural-selective transcriptional activator of the gene for Brain-Derived Neurotrophic Factor (BDNF).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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