Product Name
DTNA, Blocking Peptide
Product Synonym Names
Dystrobrevin alpha; DTN-A; Alpha-dystrobrevin; Dystrophin-related protein 3; DTNA; DRP3
Product Gene Name
DTNA blocking peptide
[Similar Products]
Product Synonym Gene Name
DRP3[Similar Products]
Antibody/Peptide Pairs
DTNA peptide (MBS9219236) is used for blocking the activity of DTNA antibody (MBS9205070)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y4J8
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cytoplasm. Cell junction, synapse. Cell membrane. Note: In peripheral nerves, colocalizes with MAGEE1 in the Schwann cell membrane.
Tissue Location
Highly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas. Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of DTNA blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
DTNA blocking peptide
May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
NCBI/Uniprot data below describe general gene information for DTNA. It may not necessarily be applicable to this product.
NCBI Accession #
Q9Y4J8.2
[Other Products]
UniProt Primary Accession #
Q9Y4J8
[Other Products]
UniProt Secondary Accession #
O15332; O15333; O75697; A8K541; A8MSZ0; A8MUY4; B4DGS6; B4DIR0; B4DIU8; M0QYX6; M0R397[Other Products]
UniProt Related Accession #
Q9Y4J8[Other Products]
Molecular Weight
58,472 Da
NCBI Official Full Name
Dystrobrevin alpha
NCBI Official Synonym Full Names
dystrobrevin alpha
NCBI Official Symbol
DTNA [Similar Products]
NCBI Official Synonym Symbols
DTN; DRP3; DTN-A; LVNC1; D18S892E
[Similar Products]
NCBI Protein Information
dystrobrevin alpha
UniProt Protein Name
Dystrobrevin alpha
UniProt Synonym Protein Names
Alpha-dystrobrevin; Dystrophin-related protein 3
Protein Family
Dystrobrevin
UniProt Gene Name
DTNA [Similar Products]
UniProt Synonym Gene Names
DRP3; DTN-A [Similar Products]
UniProt Entry Name
DTNA_HUMAN
NCBI Summary for DTNA
The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for DTNA
May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
Research Articles on DTNA
1. our findings suggest that novel mutations in FAM136A and DTNA genes are probably causal variants in FMD.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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