Full Product Name
IRF6 antibody
Product Synonym Names
Monoclonal IRF6; Anti-IRF6; Interferon Regulatory Factor 6; LPS; OFC6; PIT; PPS; VWS; IRF6; IRF 6; IRF-6
Product Gene Name
anti-IRF6 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O14896
Purity/Purification
IRF6 antibody was purified by affinity chromatography.
Form/Format
Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration
500 ug-1 mg/ml (lot specific)
Biological Significance
IRF6 is a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. Mutations in its gene can cause van der Woude syndrome and popliteal pterygium syndrome. This protein is involved in palate formation.
Immunogen
IRF6 antibody was raised in mouse using a full length recombinant protein of human IRF6 (NP_006138) as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-IRF6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IRF6 antibody
Mouse monoclonal IRF6 antibody
Product Categories/Family for anti-IRF6 antibody
Cytokines & Growth Factors
Applications Tested/Suitable for anti-IRF6 antibody
Western Blot (WB)
Application Notes for anti-IRF6 antibody
WB: 1:2000
Western Blot of anti-IRF6 antibody
Western Blot analysis using IRF6 antibody
Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant IRF6 protein (Right) or empty vector (Left) detected with IRF6 antibody
NCBI/Uniprot data below describe general gene information for IRF6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006138
[Other Products]
NCBI GenBank Nucleotide #
NM_006147.3
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UniProt Primary Accession #
O14896
[Other Products]
UniProt Secondary Accession #
B4DLE2; D3DT90; F5GWX8; G0ZTL0[Other Products]
UniProt Related Accession #
O14896[Other Products]
Molecular Weight
41,930 Da
NCBI Official Full Name
interferon regulatory factor 6 isoform 1
NCBI Official Synonym Full Names
interferon regulatory factor 6
NCBI Official Symbol
IRF6 [Similar Products]
NCBI Official Synonym Symbols
LPS; PIT; PPS; VWS; OFC6; PPS1; VWS1
[Similar Products]
NCBI Protein Information
interferon regulatory factor 6
UniProt Protein Name
Interferon regulatory factor 6
Protein Family
Interferon regulatory factor
UniProt Gene Name
IRF6 [Similar Products]
UniProt Synonym Gene Names
IRF-6 [Similar Products]
UniProt Entry Name
IRF6_HUMAN
NCBI Summary for IRF6
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]
UniProt Comments for IRF6
IRF6: Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Interacts with SERPINB5. Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. Belongs to the IRF family.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 1q32.3-q41
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: keratinocyte differentiation; negative regulation of cell proliferation; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; keratinocyte proliferation; cell cycle arrest; cell development
Disease: Orofacial Cleft 6, Susceptibility To; Popliteal Pterygium Syndrome; Van Der Woude Syndrome 1
Research Articles on IRF6
1. Ser-413 and Ser-424 in IRF6 are important for its activation by RIPK4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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