Full Product Name
Anti-human CD71 Antibody APC Conjugated, Flow Validated
Product Synonym Names
Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; CD71; Transferrin receptor protein 1; serum form; sTfR; TFRC
Product Gene Name
anti-CD71 antibody
[Similar Products]
Product Synonym Gene Name
TFRC[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P02786
Purity/Purification
Protein A purified
Immunogen
Human acute lymphoblastic leukemia cells
Subcellular Localization
Cell membrane; Single-pass type II membrane protein. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Sensitivity
5ul per sample
Contents
PBS, pH7.2, 0.09% NaN3 and 0.2% (w/v) BSA
Preparation and Storage
Store at 4 degree C and protect from prolonged exposure to light. Do not freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-CD71 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD71 antibody
Description: CD71 is also known as transferrin receptor(TFRC). Nikinmaa and Schroder(1987) concluded that p90 and TFRC are the same protein: studies using monoclonal antibodies indicated that exhaustive precipitation of radioactively labeled lysates with one antibody removed all activity of lysates with the other. Peptide maps of antigens recognized with both antibodies showed great similarity and indicated that both antibodies react with the same antigen, the human transferrin receptor, but with different antigenic sites of the molecule.TFR is assigned to chromosome 3.
Protein Function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal .
Product Categories/Family for anti-CD71 antibody
Cardiovascular; Blood; Serum Proteins; Immunology; Cell Type Markers; Non-Lineage; Stem Cells; Neural Stem Cells; Surface Molecules; Hematopoietic Progenitors; Lymphoid; B Lymphocytic Lineage; T Lymphocytic Lineage; Myeloid; Erythrocytic Lineage; Cancer;
Applications Tested/Suitable for anti-CD71 antibody
Flow Cytometry (FC/FACS)
Testing Data of anti-CD71 antibody
Jurkat E6.1 cell lines stained withanti-human CD71 APC (cloneOKT9) (red histogram). Jurkat E6.1cell lines stained with IgG1 MOPC-31C APC isotype control (bluehistogram)
NCBI/Uniprot data below describe general gene information for CD71. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001121620.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001128148.2
[Other Products]
UniProt Primary Accession #
P02786
[Other Products]
UniProt Secondary Accession #
Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21; D3DXB0[Other Products]
UniProt Related Accession #
P02786[Other Products]
Molecular Weight
84871 MW
NCBI Official Full Name
transferrin receptor protein 1 isoform 1
NCBI Official Synonym Full Names
transferrin receptor
NCBI Official Symbol
TFRC [Similar Products]
NCBI Official Synonym Symbols
T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
[Similar Products]
NCBI Protein Information
transferrin receptor protein 1
UniProt Protein Name
Transferrin receptor protein 1
UniProt Synonym Protein Names
T9; p90; CD_antigen: CD71
UniProt Gene Name
TFRC [Similar Products]
UniProt Synonym Gene Names
TR; TfR; TfR1; Trfr; sTfR [Similar Products]
NCBI Summary for CD71
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
UniProt Comments for CD71
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal . Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
Research Articles on CD71
1. results suggest that lower Hepcidin-25, as well as higher sTfR and sTfR/Hepcidin-25 ratio were significant predictors of favorable hemoglobin response within a month after IV administration of ferric carboxymaltose in patients with CKD
Precautions
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Disclaimer
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