Product Name
APG16L, Polyclonal Antibody
Full Product Name
APG16L Polyclonal Antibody
Product Gene Name
anti-APG16L antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q676U5
Form/Format
Purified (Liquid)
Concentration
0.5mg/ml, 200µl (lot specific)
Immunogen
A partial recombinant APG16L protein (amino acids 35-260) was used as the immunogen for this antibody.
Preparation and Storage
Store antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.
Other Notes
Small volumes of anti-APG16L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-APG16L antibody
Development
Applications Tested/Suitable for anti-APG16L antibody
Western Blot (WB)
Application Notes for anti-APG16L antibody
Western Blot: 2-4 µg/ml
Western Blot (WB) of anti-APG16L antibody
Expression analysis of APG16L. Anti-APG16L antibody (11-10020) was used at 4 µg/ml on Spleen lysate.
NCBI/Uniprot data below describe general gene information for APG16L. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001177195.1
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NCBI GenBank Nucleotide #
NM_001190266.1
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UniProt Primary Accession #
Q676U5
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UniProt Secondary Accession #
Q6IPN1; Q6UXW4; Q6ZVZ5; Q8NCY2; Q96JV5; Q9H619; A3EXK9; A3EXL0; B6ZDH0[Other Products]
UniProt Related Accession #
Q676U5[Other Products]
Molecular Weight
49,486 Da
NCBI Official Full Name
autophagy-related protein 16-1 isoform 4
NCBI Official Synonym Full Names
autophagy related 16-like 1
NCBI Official Symbol
ATG16L1 [Similar Products]
NCBI Official Synonym Symbols
IBD10; WDR30; APG16L; ATG16A; ATG16L
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NCBI Protein Information
autophagy-related protein 16-1; APG16L beta; ATG16 autophagy related 16-like 1; WD repeat domain 30
UniProt Protein Name
Autophagy-related protein 16-1
UniProt Synonym Protein Names
APG16-like 1
UniProt Gene Name
ATG16L1 [Similar Products]
UniProt Synonym Gene Names
APG16L [Similar Products]
UniProt Entry Name
A16L1_HUMAN
NCBI Summary for APG16L
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
UniProt Comments for APG16L
ATG16: Plays an essential role in autophagy. Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Belongs to the WD repeat ATG16 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, peripheral; Autophagy; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: pre-autophagosomal structure membrane; autophagic vacuole; axoneme
Molecular Function: identical protein binding; protein binding
Biological Process: protein transport; protein homooligomerization; autophagic vacuole formation
Disease: Inflammatory Bowel Disease 10
Research Articles on APG16L
1. Data suggest ATG16L1 dimer interacts with WIPI2b (WD repeat domain phosphoinositide-interacting protein 2) and this interaction is linked to phosphatidylinositol 3-phosphate production in endoplasmic reticulum and autophagosome formation. [REVIEW]
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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