Product Name
ATG16 (ATG16L1), Blocking Peptide
Full Product Name
ATG16 Peptide
Product Synonym Names
IBD10; WDR30; APG16L; ATG16A; ATG16L; UNQ9393/PRO34307; Autophagy-related protein 16-1; APG16-like 1; ATG16 autophagy related 16-like 1 (S. cerevisiae)
Product Gene Name
ATG16L1 blocking peptide
[Similar Products]
ATG16 peptide (MBS152802) is used for blocking the activity of ATG16 antibody (MBS151118)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q676U5
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
18 amino acids near the center of human ATG16.
Preparation and Storage
Store ATG16 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of ATG16L1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for ATG16L1 blocking peptide
Blocking (BL)
Application Notes for ATG16L1 blocking peptide
ATG16 peptide is used for blocking the activity of ATG16 antibody.
NCBI/Uniprot data below describe general gene information for ATG16L1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_110430
[Other Products]
NCBI GenBank Nucleotide #
NM_030803.6
[Other Products]
UniProt Primary Accession #
Q676U5
[Other Products]
UniProt Secondary Accession #
Q6IPN1; Q6UXW4; Q6ZVZ5; Q8NCY2; Q96JV5; Q9H619; A3EXK9; A3EXL0; B6ZDH0[Other Products]
UniProt Related Accession #
Q676U5[Other Products]
Molecular Weight
49,486 Da
NCBI Official Full Name
autophagy-related protein 16-1 isoform 1
NCBI Official Synonym Full Names
autophagy related 16-like 1 (S. cerevisiae)
NCBI Official Symbol
ATG16L1 [Similar Products]
NCBI Official Synonym Symbols
IBD10; WDR30; APG16L; ATG16A; ATG16L
[Similar Products]
NCBI Protein Information
autophagy-related protein 16-1; APG16L beta; WD repeat domain 30; ATG16 autophagy related 16-like 1
UniProt Protein Name
Autophagy-related protein 16-1
UniProt Synonym Protein Names
APG16-like 1
Protein Family
Autophagy-related protein
UniProt Gene Name
ATG16L1 [Similar Products]
UniProt Synonym Gene Names
APG16L [Similar Products]
UniProt Entry Name
A16L1_HUMAN
NCBI Summary for ATG16L1
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
UniProt Comments for ATG16L1
ATG16: Plays an essential role in autophagy. Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Belongs to the WD repeat ATG16 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, peripheral; Autophagy; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: pre-autophagosomal structure membrane; autophagic vacuole; axoneme
Molecular Function: identical protein binding; protein binding
Biological Process: protein transport; protein homooligomerization; autophagic vacuole formation
Disease: Inflammatory Bowel Disease 10
Research Articles on ATG16L1
1. Presence of Mycobacterium avium subspecies paratuberculosis, rs2241880 (ATG16L1) and rs10045431 (IL12B) were found to be significantly associated with Crohn's disease.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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