Notch 3, Antibody

For Research Use Only. Not for use in diagnostic procedures.

Affinity Purified - Liquid

Small volumes of anti-Notch3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The Notch protein sits like a trigger penetrating the cell membrane, with part of it inside and part outside. Proteins when binding to the exterior part cause the release of a portion of the interior part, which typically then makes its way to the cell nucleus to alter gene expression. The Notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine rich EGF like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1,Notch2, Notch3 and Notch4(Int3), which have been implicated in the differentiation of the nervous system and other structures. The EGF like proteins Delta and Serrate have been identified as ligands of Notch1.

Antibodies; Stem Cell Research Antibodies; Notch3

Immunohistochemistry (IHC), Western Blot (WB)

Image: Notch3 staining of rat cerebellum (Bergmann glia-10 micron cryostat sections). Working dilution is 1:100-1:300. Stained tissue was mounted under i-Brite Plus mounting media

243,631 Da

notch 3

neurogenic locus notch homolog protein 3

Neurogenic locus notch homolog protein 3

Notch 3  [Similar Products]

NOTC3_HUMAN

NOTCH3: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Heterodimer of a C-terminal fragment N(TM) and a N- terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with PSMA1. Interacts with HIF1AN. Ubiquitously expressed in fetal and ***** tissues. Belongs to the NOTCH family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.2-p13.1

Cellular Component: actin cytoskeleton; cell-cell adherens junction; cytoplasm; cytosol; endoplasmic reticulum membrane; extracellular region; Golgi membrane; nucleoplasm; plasma membrane; receptor complex

Molecular Function: protein binding

Biological Process: Notch receptor processing; Notch signaling pathway; transcription initiation from RNA polymerase II promoter

Disease: Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy; Lateral Meningocele Syndrome; Myofibromatosis, Infantile, 2

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