Product Name
ATG16L (ATG16L1), Blocking Peptide
Full Product Name
ATG16L Antibody (C-term) Blocking peptide
Product Synonym Names
Autophagy-related protein 16-1; APG16-like 1; ATG16L1; APG16L
Product Gene Name
ATG16L1 blocking peptide
[Similar Products]
Product Synonym Gene Name
APG16L[Similar Products]
Antibody/Peptide Pairs
ATG16L peptide (MBS9223212) is used for blocking the activity of ATG16L antibody (MBS9208756)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q676U5
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human Autophagy APG16L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Cellular Location
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note: Recruited to omegasomes membranes by WIPI2 Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of ATG16L1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ATG16L1 blocking peptide
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.
NCBI/Uniprot data below describe general gene information for ATG16L1. It may not necessarily be applicable to this product.
NCBI Accession #
Q676U5.2
[Other Products]
UniProt Primary Accession #
Q676U5
[Other Products]
UniProt Secondary Accession #
Q6IPN1; Q6UXW4; Q6ZVZ5; Q8NCY2; Q96JV5; Q9H619; A3EXK9; A3EXL0; B6ZDH0[Other Products]
UniProt Related Accession #
Q676U5[Other Products]
Molecular Weight
49,486 Da
NCBI Official Full Name
Autophagy-related protein 16-1
NCBI Official Synonym Full Names
autophagy related 16 like 1
NCBI Official Symbol
ATG16L1 [Similar Products]
NCBI Official Synonym Symbols
IBD10; WDR30; APG16L; ATG16A; ATG16L
[Similar Products]
NCBI Protein Information
autophagy-related protein 16-1
UniProt Protein Name
Autophagy-related protein 16-1
UniProt Synonym Protein Names
APG16-like 1
Protein Family
Autophagy-related protein
UniProt Gene Name
ATG16L1 [Similar Products]
UniProt Synonym Gene Names
APG16L [Similar Products]
UniProt Entry Name
A16L1_HUMAN
NCBI Summary for ATG16L1
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
UniProt Comments for ATG16L1
ATG16L1: Plays an essential role in autophagy. Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Belongs to the WD repeat ATG16 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Autophagy; Adaptor/scaffold; Membrane protein, peripheral
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: autophagic vacuole; axoneme; cytosol
Molecular Function: identical protein binding; protein binding; small conjugating protein ligase activity
Biological Process: autophagic vacuole formation; macroautophagy
Disease: Inflammatory Bowel Disease 10
Research Articles on ATG16L1
1. The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
