AKR1B1 / Aldose Reductase, Polyclonal Antibody

Rabbit Polyclonal (IgG) to Human AKR1B1 / Aldose Reductase; Human AKR1B1 / Aldose Reductase; Aldose reductase; ALDR1; ADR; Aldehyde reductase; Aldehyde reductase 1; ALR2; Lii5-2 CTCL tumor antigen; Low Km aldose reductase

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

AKR1B1 Antibody detects endogenous levels of total AKR1B1 protein.

Immunoaffinity purified

PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol

1 mg/ml (lot specific)

Store at -20 degree C for up to one year.

Small volumes of anti-AKR1B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

AKR1B1 Antibody, Aldose reductase Antibody, ALDR1 Antibody, ADR Antibody, Aldehyde reductase Antibody, Aldehyde reductase 1 Antibody, ALR2 Antibody, Lii5-2 CTCL tumor antigen Antibody, Low Km aldose reductase Antibody Description: AKR1B1 / Aldose Reductase is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene.

Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)

ELISA (1:20000)
IHC-P (20 ug/ml)
WB (1:500 - 1:1000)

Anti-AKR1B1 / Aldose Reductase antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Western blot of extracts from HUVEC cells, using AKR1B1 Antibody. The lane on the right is treated with the synthesized peptide.

35,853 Da

aldo-keto reductase family 1, member B1 (aldose reductase)

aldose reductase

Aldose reductase

ALDR1; AR  [Similar Products]

ALDR_HUMAN

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

AKR1B1: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. Belongs to the aldo/keto reductase family.

Protein type: Oxidoreductase; Lipid Metabolism - glycerolipid; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - fructose and mannose; EC 1.1.1.21; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - pentose and glucuronate interconversions

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: cytoplasm; cytosol; extracellular space; mast cell granule; nucleoplasm; perinuclear region of cytoplasm

Molecular Function: aldehyde reductase activity; aldo-keto reductase activity; electron carrier activity; glyceraldehyde oxidoreductase activity

Biological Process: C21-steroid hormone biosynthetic process; carbohydrate metabolic process; fructose biosynthetic process; fructose metabolic process; maternal process involved in pregnancy; naphthalene metabolic process; norepinephrine metabolic process; positive regulation of JAK-STAT cascade; positive regulation of smooth muscle cell proliferation; response to stress; response to water deprivation; sorbitol biosynthetic process; steroid metabolic process; stress-activated protein kinase signaling pathway; tissue homeostasis

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