Product Name
ACTA1, cDNA Clone
Full Product Name
ACTA1 cDNA Clone
Product Gene Name
ACTA1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgtgcgacg aagacgagac caccgccctc gtgtgcgaca atggctccgg cctggtgaaa gccggcttcg ccggggatga cgcccctagg gccgtgttcc cgtccatcgt gggccgcccc cgacaccagg gcgtcatggt cggtatgggt cagaaagatt cctacgtggg cgacgaggct cagagcaaga gaggtatcct gaccctgaag taccctatcg agcacggcat catcaccaac tgggatgaca tggagaagat ctggcaccac accttctaca acgagcttcg cgtggctccc gaggagcacc ccaccctgct caccgaggcc cccctcaatc ccaaggccaa ccgcgagaag atgacccaga tcatgtttga gaccttcaac gtgcccgcca tgtacgtggc catccaggcc gtgctgtccc tctacgcctc cggcaggacc accggcatcg tgctggactc cggcgacggc gtcacccaca acgtgcccat ttatgagggc tacgcgctgc cgcacgccat catgcgcctg gacctggcgg gccgcgatct caccgactac ctgatgaaga tcctcactga gcgtggctac tccttcgtga ccacagctga gcgcgagatc gtgcgcgaca tcaaggagaa gctgtgctac gtggccctgg acttcgagaa cgagatggcg acggccgcct cctcctcctc cctggaaaag agctacgagc tgccagacgg gcaggtcatc accatcggca acgagcgctt ccgctgcccg gagacgctct tccagccctc cttcatcggt atggagtcgg cgggcattca cgagaccacc tacaacagca tcatgaagtg tgacatcgac atcaggaagg acctgtatgc caacaacgtc atgtcggggg gcaccacgat gtaccctggg atcgctgacc gcatgcagaa agagatcacc gcgctggcac ccagcaccat gaagatcaag atcatcgccc cgccggagcg caaatactcg gtgtggatcg gcggctccat cctggcctcg ctgtccacct tccagcagat gtggatcacc aagcaggagt acgacgaggc cggcccttcc atcgtccacc gcaaatgctt ctag
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ACTA1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ACTA1. It may not necessarily be applicable to this product.
NCBI Accession #
BC012597
[Other Products]
UniProt Secondary Accession #
P02568; P99020; Q5T8M9[Other Products]
UniProt Related Accession #
P68133[Other Products]
Molecular Weight
42,051 Da
NCBI Official Full Name
Homo sapiens actin, alpha 1, skeletal muscle, mRNA
NCBI Official Synonym Full Names
actin, alpha 1, skeletal muscle
NCBI Official Symbol
ACTA1 [Similar Products]
NCBI Official Synonym Symbols
ACTA; ASMA; CFTD; MPFD; NEM1; NEM2; NEM3; SHPM; CFTD1; CFTDM
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NCBI Protein Information
actin, alpha skeletal muscle
UniProt Protein Name
Actin, alpha skeletal muscle
UniProt Synonym Protein Names
Alpha-actin-1
UniProt Gene Name
ACTA1 [Similar Products]
UniProt Synonym Gene Names
ACTA [Similar Products]
UniProt Entry Name
ACTS_HUMAN
NCBI Summary for ACTA1
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq, Jul 2008]
UniProt Comments for ACTA1
ACTA1: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID. Interacts (via its C-terminus) with USP25; the interaction occurs for all USP25 isoforms but is strongest for isoform USP25m in muscle differentiating cells. Belongs to the actin family.
Protein type: Contractile; Motility/polarity/chemotaxis; Cytoskeletal; Cell development/differentiation
Chromosomal Location of Human Ortholog: 1q42.13
Cellular Component: actin cytoskeleton; actin filament; cytosol; extracellular space; filopodium; lamellipodium; sarcomere; stress fiber; striated muscle thin filament
Molecular Function: ADP binding; ATP binding; myosin binding; protein binding; structural constituent of cytoskeleton
Biological Process: muscle contraction; muscle filament sliding; muscle thin filament assembly; skeletal muscle fiber development
Disease: Myopathy, Congenital, With Fiber-type Disproportion; Myopathy, Scapulohumeroperoneal; Nemaline Myopathy 3
Research Articles on ACTA1
1. Upon actin engagement, the N-terminal "strap" and helix 1 are displaced from the vinculin tail helical bundle to mediate actin bundling.
Precautions
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Disclaimer
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