ATP6V1B2, Antibody

For Research Use Only. Not for use in diagnostic procedures.

Rabbit

1.0mg/ml (lot specific)

Small volumes of anti-ATP6V1B2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB)

56,501 Da

ATPase H+ transporting V1 subunit B2

V-type proton ATPase subunit B, brain isoform

V-type proton ATPase subunit B, brain isoform

ATP6B2; VPP3; V-ATPase subunit B 2  [Similar Products]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]

ATP6V1B2: Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the ATPase alpha/beta chains family.

Protein type: EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: cytosol; intracellular membrane-bound organelle; lysosomal membrane; plasma membrane

Molecular Function: hydrogen ion transmembrane transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism; protein binding

Biological Process: insulin receptor signaling pathway; proton transport; transferrin transport

Disease: Deafness, Congenital, With Onychodystrophy, Autosomal Dominant; Zimmermann-laband Syndrome 2

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