ATP6V1B2, Monoclonal Antibody

Mouse Monoclonal [clone 2A5] (IgG1, k) to Human ATP6V1B2; ATP6V1B2; ATP6B1B2; ATP6B2; V-ATPase subunit B 2; Vma2; VATB; VPP3; HO57; V-ATPase B2 subunit

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG2a

1E11

Mouse

Human ATP6V1B2

Protein A/G purified

PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide

Store at -20 degree C.
Avoid freeze-thaw cycles.

Small volumes of anti-ATP6V1B2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ATP6V1B2 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain.

Transporter; ATPase - V type

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-P: 1:100-1:150
WB: 1:2000

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ATP6V1B2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ATP6V1B2.

56,501 Da

ATPase H+ transporting V1 subunit B2

V-type proton ATPase subunit B, brain isoform

V-type proton ATPase subunit B, brain isoform

ATP6B2; VPP3; V-ATPase subunit B 2  [Similar Products]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

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