Product Name
5-hydroxytryptamine receptor 6 (HTR6), Recombinant Protein
Full Product Name
Recombinant Human 5-hydroxytryptamine receptor 6 (HTR6)
Product Synonym Names
Recombinant 5-hydroxytryptamine receptor 6 (HTR6); 5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6
Product Gene Name
HTR6 recombinant protein
[Similar Products]
Product Synonym Gene Name
HTR6[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MVPEPGPTAN STPAWGAGPP SAPGGSGWVA AALCVVIALT AAANSLLIAL ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTP LRALALVLGA WSLAALASFL PLLLGWHELG HARPPVPGQC RLLASLPFVL VASGLTFFLP SGAICFTYCR ILLAARKQAV QVASLTTGMA SQASETLQVP RTPRPGVESA DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIV QAVCDCISPG LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCPRC PRERQASLAS PSLRTSHSGP RPGLSLQQVL PLPLPPDSDS DSDAGSGGSS GLRLTAQLLL PGEATQDPPL PTRAAAAVNF FNIDPAEPEL RPHPLGIPTN
Chromosome Location
Chromosome: 1; NC_000001.10 (19991780..20006055). Location: 1p36-p35
3D Structure
ModBase 3D Structure for P50406
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of HTR6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for HTR6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000862.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000871.1
[Other Products]
UniProt Primary Accession #
P50406
[Other Products]
UniProt Secondary Accession #
Q13640; Q5TGZ1[Other Products]
UniProt Related Accession #
P50406[Other Products]
Molecular Weight
46,954 Da[Similar Products]
NCBI Official Full Name
5-hydroxytryptamine receptor 6
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
NCBI Official Symbol
HTR6 [Similar Products]
NCBI Official Synonym Symbols
5-HT6; 5-HT6R
[Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 6; 5-HT-6; serotonin receptor 6
UniProt Protein Name
5-hydroxytryptamine receptor 6
UniProt Synonym Protein Names
Serotonin receptor 6
Protein Family
5-hydroxytryptamine receptor
UniProt Gene Name
HTR6 [Similar Products]
UniProt Synonym Gene Names
5-HT-6; 5-HT6 [Similar Products]
UniProt Entry Name
5HT6R_HUMAN
NCBI Summary for HTR6
This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
UniProt Comments for HTR6
5-HT(6): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p36-p35
Cellular Component: integral to plasma membrane; dendrite; plasma membrane; cilium
Molecular Function: protein binding; serotonin receptor activity; histamine receptor activity
Biological Process: response to drug; positive regulation of dopamine secretion; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; cerebral cortex cell migration; negative regulation of glutamate secretion; negative regulation of gamma-aminobutyric acid secretion; negative regulation of acetylcholine secretion; learning; response to estradiol stimulus; positive regulation of TOR signaling pathway; serotonin receptor signaling pathway; positive regulation of gamma-aminobutyric acid secretion
Research Articles on HTR6
1. There was a statistically significant difference in semantic memory scores among the three genotype groups of T267C in 5-HT6.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
