Full Product Name
LHX4 (Lim Region Containing Transcription Factor)
Product Synonym Names
Anti -LHX4 (Lim Region Containing Transcription Factor)
Product Gene Name
anti-LHX4 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (180199442..180244188). Location: 1q25.2
3D Structure
ModBase 3D Structure for Q969G2
Species Reactivity
Human, Rodent
Specificity
Recognizes human LHX4, a LIM region containing transcription factor. Species Crossreactivity: rodent.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide, before the addition of glycerol to 40%.
Immunogen
Synthetic peptide, aa142-158, EDYETAKQNDDSEAGAK corresponding to human LHX4 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-LHX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LHX4 antibody
Lhx4 (also known as Gsh4) is a member of the LIM-homeobox gene family and plays a critical role in the development of motor neurons.
Product Categories/Family for anti-LHX4 antibody
Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-LHX4 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-LHX4 antibody
Suitable for use in ELISA, Immunohistochemistry and Western Blot.
Dilution: ELISA (titer): 137,500.
Western Blot: Strong band detected at 23, 40, 65, 75 using mouse placenta.
Immunohistochemistry: 5ug/ml
NCBI/Uniprot data below describe general gene information for LHX4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_203129.1
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NCBI GenBank Nucleotide #
NM_033343.3
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UniProt Primary Accession #
Q969G2
[Other Products]
UniProt Secondary Accession #
Q8NHE0; Q8NHM1; Q8TCJ1; Q8WWX2; Q969W2[Other Products]
UniProt Related Accession #
Q5RLJ1; Q5RLJ2; Q5RLJ3; Q969G2; Q96JP7[Other Products]
Molecular Weight
40.83kD.[Similar Products]
NCBI Official Full Name
LIM/homeobox protein Lhx4
NCBI Official Synonym Full Names
LIM homeobox 4
NCBI Official Symbol
LHX4 [Similar Products]
NCBI Official Synonym Symbols
CPHD4; FLJ22769
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NCBI Protein Information
LIM/homeobox protein Lhx4; OTTHUMP00000033083; LIM homeobox protein 4
UniProt Protein Name
LIM/homeobox protein Lhx4
Protein Family
LIM/homeobox protein
UniProt Gene Name
LHX4 [Similar Products]
UniProt Entry Name
LHX4_HUMAN
NCBI Summary for LHX4
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq]
UniProt Comments for LHX4
LHX4: May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Defects in LHX4 are the cause of pituitary hormone deficiency combined type 4 (CPHD4); also known as short stature pituitary and cerebellar defects and small sella turcica. The disorder is characterized by short stature, pituitary and cerebellar defects, and small transverse depression crossing the midline on the superior surface of the body of the sphenoid bone which houses the pituitary gland. A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1.
Protein type: Oncoprotein; DNA-binding
Chromosomal Location of Human Ortholog: 1q25.2
Cellular Component: nucleus
Molecular Function: zinc ion binding; sequence-specific DNA binding
Biological Process: organ morphogenesis; transcription, DNA-dependent; regulation of transcription, DNA-dependent; motor axon guidance; medial motor column neuron differentiation; placenta development; negative regulation of apoptosis
Disease: Pituitary Hormone Deficiency, Combined, 4
Research Articles on LHX4
1. A novel HESX1 causative mutation was found in a consanguineous family, and two LHX4 mutations were present in familial Pituitary stalk interruption syndrome.
Precautions
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Disclaimer
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