RLBP1, Polyclonal Antibody

Purified Rabbit Polyclonal Antibody (Pab); Retinaldehyde-binding protein 1; Cellular retinaldehyde-binding protein; RLBP1; CRALBP

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Ig

Rabbit

This RLBP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 255-288 amino acids from the C-terminal region of human RLBP1.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-RLBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.

Neuroscience

Western Blot (WB)

WB ~~ 1:2000

Anti-RLBP1 Antibody (C-term) at 1:2000 dilution + mouse eyeball lysate

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 36 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

36474

retinaldehyde binding protein 1

retinaldehyde-binding protein 1

Retinaldehyde-binding protein 1

CRALBP  [Similar Products]

RLBP1_HUMAN

The protein encoded by this gene is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (nonsyndromic autosomal recessive retinitis pigmentosa) and retinitis punctata albescens. [provided by RefSeq, Jul 2008]

RLBP1: Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'. Defects in RLBP1 are a cause of retinitis pigmentosa autosomal recessive (ARRP). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Defects in RLBP1 are the cause of Bothnia retinal dystrophy (BRD); also known as Vasterbotten dystrophy. Affected individuals show night blindness from early childhood with features consistent with retinitis punctata albescens and macular degeneration. Defects in RLBP1 are the cause of rod-cone dystrophy Newfoundland (NFRCD). NFRCD is a retinal dystrophy reminiscent of retinitis punctata albescens but with a substantially lower age at onset and more-rapid and distinctive progression. Rod-cone dystrophies results from initial loss of rod photoreceptors, later followed by cone photoreceptors loss. Defects in RLBP1 are a cause of retinitis punctata albescens (RPA). A rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments.

Chromosomal Location of Human Ortholog: 15q26

Cellular Component: cytosol

Molecular Function: transporter activity; 11-cis retinal binding; retinol binding

Biological Process: phototransduction, visible light; visual perception; transport; retinoid metabolic process; vitamin A metabolic process

Disease: Fundus Albipunctatus; Bothnia Retinal Dystrophy; Newfoundland Rod-cone Dystrophy

Crabb J.W.,et al.J. Biol. Chem. 263:18688-18692(1988). Intres R.,et al.J. Biol. Chem. 269:25411-25418(1994). Ota T.,et al.Nat. Genet. 36:40-45(2004). Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Crabb J.W.,et al.Protein Sci. 7:746-757(1998).

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