Full Product Name
RLBP1 Antibody - N-terminal region
Product Gene Name
anti-RLBP1 antibody
[Similar Products]
Product Synonym Gene Name
CRALBP[Similar Products]
Antibody/Peptide Pairs
RLBP1 peptide (MBS3239440) is used for blocking the activity of RLBP1 antibody (MBS3214503)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: ELNEREETRE EAVRELQEMV QAQAASGEEL AVAVAERVQE KDSGFFLRFI
3D Structure
ModBase 3D Structure for P12271
Species Reactivity
Cow, Dog, Guinea Pig, Human, Pig, Rat
Purity/Purification
Affinity purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 86%; Dog: 79%; Guinea Pig: 79%; Human: 100%; Pig: 86%; Rat: 79%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human RLBP1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-RLBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RLBP1 antibody
retinaldehyde binding protein 1
Target Description: The protein encoded by this gene is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (nonsyndromic autosomal recessive retinitis pigmentosa) and retinitis punctata albescens.
Product Categories/Family for anti-RLBP1 antibody
Polyclonal; Disease Related;
Applications Tested/Suitable for anti-RLBP1 antibody
Western Blot (WB)
Western Blot (WB) of anti-RLBP1 antibody
Host: Rabbit
Target Name: RLBP1
Sample Tissue: Human Uterus Tumor lysates
Antibody Dilution: 1ug/ml
NCBI/Uniprot data below describe general gene information for RLBP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000317
[Other Products]
NCBI GenBank Nucleotide #
NM_000326.4
[Other Products]
UniProt Primary Accession #
P12271
[Other Products]
NCBI Official Full Name
retinaldehyde-binding protein 1
UniProt Protein Name
Retinaldehyde-binding protein 1
UniProt Synonym Protein Names
Cellular retinaldehyde-binding protein
Protein Family
Retinaldehyde-binding protein
UniProt Gene Name
RLBP1 [Similar Products]
UniProt Synonym Gene Names
CRALBP [Similar Products]
UniProt Comments for RLBP1
RLBP1: Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'. Defects in RLBP1 are a cause of retinitis pigmentosa autosomal recessive (ARRP). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Defects in RLBP1 are the cause of Bothnia retinal dystrophy (BRD); also known as Vasterbotten dystrophy. Affected individuals show night blindness from early childhood with features consistent with retinitis punctata albescens and macular degeneration. Defects in RLBP1 are the cause of rod-cone dystrophy Newfoundland (NFRCD). NFRCD is a retinal dystrophy reminiscent of retinitis punctata albescens but with a substantially lower age at onset and more-rapid and distinctive progression. Rod-cone dystrophies results from initial loss of rod photoreceptors, later followed by cone photoreceptors loss. Defects in RLBP1 are a cause of retinitis punctata albescens (RPA). A rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments.
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: cytosol
Biological Process: retinoid metabolic process; vitamin A metabolic process
Disease: Bothnia Retinal Dystrophy; Fundus Albipunctatus; Newfoundland Rod-cone Dystrophy
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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