CD132, Monoclonal Antibody

Cytokine receptor common subunit gamma; Il2rg; Interleukin-2 receptor subunit gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; gammaC; p64; CD132

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG2b, kappa

3E12

Rat

PBS with 0.05% Proclin300, 1% BSA

0.5 mg/mL (lot specific)

Store at 2-8 degree C and protect from prolonged exposure to light. Do not freeze.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-CD132 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, and is also known as common gamma chain (gammac) or IL-2 receptor gamma subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Ligand binding induces tyrosine phosphorylation and initiates signaling through a JAK/STAT pathway. CD132 mutation results in X-linked severe combined immune deficiency (XSCID).

Flow Cytometry (FC/FACS)

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is <= 2 ug per 10⁶ cells in 100 ul volume or 100 ul of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

interleukin 2 receptor, gamma chain

cytokine receptor common subunit gamma

Cytokine receptor common subunit gamma

IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG  [Similar Products]

IL2RG_MOUSE

This gene encodes a transmembrane protein that is a common subunit of several interleukin receptor complexes. These receptors are comprised of alpha and beta subunits in addition to this gamma subunit. Signalling through this pathway in important in immune cell differentiation and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

IL2RG: Common subunit for the receptors for a variety of interleukins. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell- negative (XSCID); also known as agammaglobulinemia Swiss type. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell- mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID). XCID is a less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID. Belongs to the type I cytokine receptor family. Type 5 subfamily.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane; external side of plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-7 binding; interleukin-2 binding

Biological Process: positive regulation of T cell differentiation in the thymus; positive regulation of lymphocyte differentiation; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; regulation of gene expression; positive regulation of B cell differentiation

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