Full Product Name
NUMBL Monoclonal Antibody
Product Synonym Names
CAG 3A; CAG3A; CTG 3a; CTG3a; NBL; NUMB Drosophilia Homolog Like; Numb homolog (Drosophila) like; Numb homolog like; Numb like protein; NUMB R; Numb-like protein; Numb-R; Numb-related gene; Numb-related protein; NUMBL; NUMBL; NUMBLIKE; NUMBR; TNRC 23; TNRC23; Trinucleotide repeat-containing gene 23
Product Gene Name
anti-NUMBL antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
604018 geneneXtProt; the human protein knowledge platformMore
3D Structure
ModBase 3D Structure for Q9Y6R0
Purity/Purification
Protein A purification
Concentration
1mg/mL (lot specific)
Immunogen
Fusion protein of NUMBL
Buffer
PBS with 0.02% sodium azide, 50% glycerol, PH7.3
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-NUMBL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NUMBL antibody
Numbl (also known as numblike or Nbl), as a conserved homolog of Drosophila Numb, is specfically expressed in the brain. Numbl is a cytoplasm protein and has redundant functions in embryonic neurogenesis. It plays an important role in ependymal wall integrity and subventricular zone neuroblast survival. However, its expression and function in the central nervous system lesion are still unclear.
Product Categories/Family for anti-NUMBL antibody
Cancer; Neuroscience; Stem cells
Applications Tested/Suitable for anti-NUMBL antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-NUMBL antibody
WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:20-1:200
Western Blot (WB) of anti-NUMBL antibody
Western Blot analysis of L02 cells using NUMBL Monoclonal Antibody at dilution of 1:1000
NCBI/Uniprot data below describe general gene information for NUMBL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001276908.1
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NCBI GenBank Nucleotide #
NM_001289979.1
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UniProt Primary Accession #
Q9Y6R0
[Other Products]
UniProt Secondary Accession #
Q7Z4J9[Other Products]
UniProt Related Accession #
Q9Y6R0[Other Products]
Molecular Weight
Calculated: 65kDa
Observed: 70kDa
NCBI Official Full Name
numb-like protein isoform b
NCBI Official Synonym Full Names
NUMB like, endocytic adaptor protein
NCBI Official Symbol
NUMBL [Similar Products]
NCBI Official Synonym Symbols
NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE
[Similar Products]
NCBI Protein Information
numb-like protein
UniProt Protein Name
Numb-like protein
UniProt Synonym Protein Names
Numb-related protein; Numb-R
Protein Family
Numb-like protein
UniProt Gene Name
NUMBL [Similar Products]
UniProt Synonym Gene Names
Numb-R [Similar Products]
UniProt Comments for NUMBL
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
Research Articles on NUMBL
1. NumbL can act as an independent tumor suppressor inhibiting the Notch pathway and regulating the cancer stem cell pool
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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