Full Product Name
Anti-NUMBL Antibody
Product Gene Name
anti-NUMBL antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y6R0
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Immunogen
Recombinant protein of human NUMBL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-NUMBL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NUMBL antibody
Numb-like (Numbl or Nbl) binds Notch and is an intracellular modulator of Notch signaling pathway. Numbl contains a phosphotyrosine binding (PTB) domain that could bind the Y682 motif present in the cytoplasmic tail of APP.
Applications Tested/Suitable for anti-NUMBL antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-NUMBL antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
NCBI/Uniprot data below describe general gene information for NUMBL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001276908.1
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NCBI GenBank Nucleotide #
NM_001289979.1
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UniProt Primary Accession #
Q9Y6R0
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UniProt Secondary Accession #
Q7Z4J9[Other Products]
UniProt Related Accession #
Q9Y6R0[Other Products]
Molecular Weight
64,891 Da
NCBI Official Full Name
numb-like protein isoform b
NCBI Official Synonym Full Names
NUMB like, endocytic adaptor protein
NCBI Official Symbol
NUMBL [Similar Products]
NCBI Official Synonym Symbols
NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE
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NCBI Protein Information
numb-like protein
UniProt Protein Name
Numb-like protein
UniProt Synonym Protein Names
Numb-related protein; Numb-R
Protein Family
Numb-like protein
UniProt Gene Name
NUMBL [Similar Products]
UniProt Synonym Gene Names
Numb-R [Similar Products]
UniProt Comments for NUMBL
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
Research Articles on NUMBL
1. NumbL can act as an independent tumor suppressor inhibiting the Notch pathway and regulating the cancer stem cell pool
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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