Product Name
Leucine zipper putative tumor suppressor 1 (Lzts1), Recombinant Protein
Full Product Name
Recombinant Mouse Leucine zipper putative tumor suppressor 1 (Lzts1)
Product Gene Name
Lzts1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-599aa, Full Length of Mature Protein
Sequence
GSVSSLISGH SFHSKHCRAS QYKLRKSSHL KKLNRYSDGL LRFGFSQDSG RGKSSSKMGK SEDFFYIKVS QKARGSHRPD YTALSSGDIG GQTGVDFDPA TPPKLMPFSN QLEMSSDKGA VRPTAFKPVL PRSGAILHSS PESTSHQLHP MPPDKPKEQE LKPGLCSGAL SDSGRNSMSS LPTHSTTSSY QLDPLVTPVG PTSRFGGSAH NITQGIILQD SNMMSLKALS FSDGGSKLAH PGKADKGASC VRSPLSTDEC TIQELEQKLL QRETALQKLQ RSFDEKEFAS GQTFEERPRR TRDELECLEP KSKLKPPSQK SQRTQQVLQL QVLQLQQEKR QLRQELESLM KEQDLLETKL RSYEREKTNF APALEETQWE VCQKSGEISL LKQQLKESQL EVNTKASEIL SLKAQLKDTR GKLDGMELKT QDLESALRTK GLELEVCENE LQRKKNEAEL LREKVNLLEQ ELMELRAQAA LHPAPLGPPG VGLTFSEDIP ALQRELDRLR AELKEERQGH DQMSSGFQHE RLVWKEEKEK VIQYQRQLQQ SYLAMYQRNQ RLEKALQQLA RGDGPGEPFE IDLEGADIPY EDIIATEI
3D Structure
ModBase 3D Structure for P60853
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Lzts1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Lzts1 recombinant protein
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1
cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer.
NCBI/Uniprot data below describe general gene information for Lzts1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_955396.2
[Other Products]
NCBI GenBank Nucleotide #
NM_199364.2
[Other Products]
UniProt Primary Accession #
P60853
[Other Products]
UniProt Secondary Accession #
B2RTI1[Other Products]
UniProt Related Accession #
P60853[Other Products]
Molecular Weight
67,290 Da
NCBI Official Full Name
leucine zipper putative tumor suppressor 1
NCBI Official Synonym Full Names
leucine zipper, putative tumor suppressor 1
NCBI Official Symbol
Lzts1 [Similar Products]
NCBI Official Synonym Symbols
F37; FEZ1; PSD-Zip70
[Similar Products]
NCBI Protein Information
leucine zipper putative tumor suppressor 1
UniProt Protein Name
Leucine zipper putative tumor suppressor 1
UniProt Synonym Protein Names
F37/Esophageal cancer-related gene-coding leucine-zipper motif; Fez1
Protein Family
Leucine zipper putative tumor suppressor
UniProt Gene Name
Lzts1 [Similar Products]
UniProt Synonym Gene Names
Fez1 [Similar Products]
UniProt Comments for Lzts1
Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor ().
Research Articles on Lzts1
1. The results of this study provide a novel Rap2-specific regulatory mechanism in synaptic maturation involving PSD-Zip70.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
