DNAI2, Polyclonal Antibody

Dynein intermediate chain 2; axonemal; Axonemal dynein intermediate chain 2; DNAI2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This DNAI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484-513 amino acids from the C-terminal region of human DNAI2.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.32 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-DNAI2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene belongs to the dynein
intermediate chain family, and is part of the dynein complex of
respiratory cilia and sperm flagella. Mutations in this gene are
associated with primary ciliary dyskinesia type 9. Alternatively
spliced transcript variants encoding different isoforms have been
noted for this gene.

Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

DNAI2 Antibody (C-term) western blot analysis in A431 cell line lysates (35ug/lane).This demonstrates the DNAI2 antibody detected the DNAI2 protein (arrow).

68821

dynein, axonemal, intermediate chain 2

dynein intermediate chain 2, axonemal

Dynein intermediate chain 2, axonemal

DNAI2_HUMAN

The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010]

DNAI2: Part of the dynein complex of respiratory cilia. Defects in DNAI2 are the cause of primary ciliary dyskinesia type 9 (CILD9). CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Belongs to the dynein intermediate chain family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Motor; Microtubule-binding

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: microtubule; axonemal dynein complex; axoneme

Molecular Function: protein binding; microtubule motor activity

Biological Process: metabolic process; cilium biogenesis

Disease: Ciliary Dyskinesia, Primary, 9

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Loges, N.T., et al. Am. J. Hum. Genet. 83(5):547-558(2008)
Pennarun, G., et al. Hum. Genet. 107(6):642-649(2000)

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