Product Synonym Names
DCOH; PCBD; PCD; PHS
Product Gene Name
anti-PCBD1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P61457
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human PCBD1
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-PCBD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PCBD1 antibody
This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants.
Applications Tested/Suitable for anti-PCBD1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-PCBD1 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IF: 1:10-1:100
NCBI/Uniprot data below describe general gene information for PCBD1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000272.1
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NCBI GenBank Nucleotide #
NM_000281.3
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UniProt Primary Accession #
P61457
[Other Products]
UniProt Secondary Accession #
P70519; P80095; Q9D930[Other Products]
UniProt Related Accession #
P61457[Other Products]
NCBI Official Full Name
pterin-4-alpha-carbinolamine dehydratase isoform 1
NCBI Official Synonym Full Names
pterin-4 alpha-carbinolamine dehydratase 1
NCBI Official Symbol
PCBD1 [Similar Products]
NCBI Official Synonym Symbols
PCD; PHS; DCOH; PCBD
[Similar Products]
NCBI Protein Information
pterin-4-alpha-carbinolamine dehydratase
UniProt Protein Name
Pterin-4-alpha-carbinolamine dehydratase
UniProt Synonym Protein Names
4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD
Protein Family
Pterin-4-alpha-carbinolamine dehydratase
UniProt Gene Name
PCBD1 [Similar Products]
UniProt Synonym Gene Names
DCOH; PCBD; PHS; DCoH; Dimerization cofactor of HNF1; PCD [Similar Products]
NCBI Summary for PCBD1
This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Comments for PCBD1
Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity.
Research Articles on PCBD1
1. We provide the first genetic evidence that PCBD1 mutations can cause early-onset nonautoimmune diabetes with features similar to dominantly inherited HNF1A-diabetes.
Precautions
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Disclaimer
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