IL-2 receptor gamma, Monoclonal Antibody

Il2rg; gc; [g]c; CD132; gamma©; Il2rg; gc; [g]c; CD132; gamma

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: X; NC_000086.7 (101264385..101268250, complement). Location: X D; X 43.9 cM

Monoclonal

IgG2

(15C5)

Rat

Lyophilized

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-IL-2 receptor gamma antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

When IL-2 R alpha is associated with the IL-2 receptor beta and gamma chains, a high affinity heterotrimeric receptor complex that transduces IL-2 signals is formed. The gamma chain is also the common signaling subunit of the high affinity receptor complex for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21.

Western Blot (WB), Flow Cytometry (FC/FACS)

42,241 Da

interleukin 2 receptor, gamma chain

cytokine receptor common subunit gamma; p64; IL-2RG; gammaC; gamma C receptor; common gamma chain; IL-2R subunit gamma; IL-2 receptor subunit gamma; interleukin-2 receptor subunit gamma; common cytokine receptor gamma chain variant b

Cytokine receptor common subunit gamma

IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG  [Similar Products]

IL2RG_MOUSE

This gene encodes a transmembrane protein that is a common subunit of several interleukin receptor complexes. These receptors are comprised of alpha and beta subunits in addition to this gamma subunit. Signalling through this pathway in important in immune cell differentiation and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

Function: Common subunit for the receptors for a variety of interleukins.

Subunit structure: The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 and probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein.

Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation.

Sequence similarities: Belongs to the type I cytokine receptor family. Type 5 subfamily.Contains 1 fibronectin type-III domain.

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