Product Name
Neuroligin 3 (NLGN3), Blocking Peptide
Full Product Name
Neuroligin 3 Immunizing Peptide
Product Synonym Names
neuroligin 3; KIAA1480; ASPGX1; AUTSX1; HNL3; NLGN3; Neuroligin 3; Neuroligin 3
Product Gene Name
NLGN3 blocking peptide
[Similar Products]
Neuroligin 3 peptide (MBS426686) is used for blocking the activity of Neuroligin 3 antibody (MBS420494)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
C-RKDKRRQE PLRQPS
Species Reactivity
Human, Mouse, Rat, Dog
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of NLGN3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for NLGN3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_061850.2
[Other Products]
NCBI GenBank Nucleotide #
NM_018977.3
[Other Products]
UniProt Secondary Accession #
Q86V51; Q8NCD0; Q9NZ95; Q9NZ96; Q9NZ97; Q9P248; B2RBK1; D2X2H6; D3DVV0; D3DVV1[Other Products]
UniProt Related Accession #
Q9NZ94[Other Products]
Molecular Weight
89,538 Da
NCBI Official Full Name
neuroligin-3 isoform 2
NCBI Official Synonym Full Names
neuroligin 3
NCBI Official Symbol
NLGN3 [Similar Products]
NCBI Official Synonym Symbols
HNL3
[Similar Products]
NCBI Protein Information
neuroligin-3
UniProt Protein Name
Neuroligin-3
UniProt Synonym Protein Names
Gliotactin homolog
Protein Family
Neuroligin
UniProt Gene Name
NLGN3 [Similar Products]
UniProt Synonym Gene Names
KIAA1480; NL3 [Similar Products]
UniProt Entry Name
NLGN3_HUMAN
NCBI Summary for NLGN3
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for NLGN3
NLGN3: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. Defects in NLGN3 may be the cause of susceptibility to autism X-linked type 1 (AUTSX1). AUTSX1 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Defects in NLGN3 may be the cause of susceptibility to X- linked Asperger syndrome 1 (ASPGX1). ASPGX1 is considered to be a form of childhood autism. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: cell junction; cell soma; cell surface; dendrite; endocytic vesicle; excitatory synapse; extracellular space; integral to plasma membrane; synapse
Molecular Function: cell adhesion molecule binding; neurexin binding; protein binding; receptor activity
Biological Process: ***** behavior; axon extension; learning; neurological control of breathing; neuron adhesion; oligodendrocyte differentiation; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; receptor-mediated endocytosis; regulation of excitatory postsynaptic membrane potential; regulation of inhibitory postsynaptic membrane potential; regulation of synaptic transmission; rhythmic synaptic transmission; social behavior; synapse organization and biogenesis; synaptogenesis; visual learning
Disease: Asperger Syndrome, X-linked, Susceptibility To, 1; Autism, Susceptibility To, X-linked 1
Research Articles on NLGN3
1. The synaptic protein neuroligin-3 (NLGN3) was identified as the leading candidate mitogen, and soluble NLGN3 was sufficient and necessary to promote robust high-grade glioma cell proliferation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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