Full Product Name
BMP1 Antibody
Product Gene Name
anti-BMP1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P13497
Species Reactivity
Human, Mouse
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-BMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BMP1 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for BMP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001190.1
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NCBI GenBank Nucleotide #
NM_001199.3
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UniProt Primary Accession #
P13497
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UniProt Secondary Accession #
Q13292; Q13872; Q14874; Q99421; Q99422; Q99423; Q9UL38; A8K6F5; B2RN46; D3DSR0[Other Products]
UniProt Related Accession #
P13497[Other Products]
Molecular Weight
92,655 Da
NCBI Official Full Name
bone morphogenetic protein 1 isoform 1
NCBI Official Synonym Full Names
bone morphogenetic protein 1
NCBI Official Symbol
BMP1 [Similar Products]
NCBI Official Synonym Symbols
PCP; TLD; OI13; PCP2; PCOLC
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NCBI Protein Information
bone morphogenetic protein 1
UniProt Protein Name
Bone morphogenetic protein 1
UniProt Synonym Protein Names
Mammalian tolloid protein; mTld; Procollagen C-proteinase; PCP
Protein Family
Bone morphogenetic protein
UniProt Gene Name
BMP1 [Similar Products]
UniProt Synonym Gene Names
PCOLC; BMP-1; mTld; PCP [Similar Products]
NCBI Summary for BMP1
This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]
UniProt Comments for BMP1
BMP1: Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Defects in BMP1 are a cause of autosomal recessive osteogenesis imperfecta (AR-OI). A connective tissue disorder characterized by bone fragility, progressively deforming bones, bowing of limbs due to multiple fractures, very short stature, a triangular face, severe scoliosis, and grayish sclera. AR-OI due to BMP1 mutations belongs to the group of osteogenesis imperfecta type III in the Sillence classification. Belongs to the peptidase M12A family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine; EC 3.4.24.19; Protease
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: extracellular region; extracellular space
Molecular Function: cytokine activity; metalloendopeptidase activity; peptidase activity; protein binding; serine-type endopeptidase activity; transforming growth factor beta receptor binding
Biological Process: BMP signaling pathway; cartilage condensation; cell development; extracellular matrix disassembly; lipoprotein metabolic process; multicellular organismal development; proteolysis; regulation of apoptosis; regulation of MAPKKK cascade
Disease: Osteogenesis Imperfecta, Type Xiii
Research Articles on BMP1
1. a previously unknown O-glycosylation site and Asn-hydroxylation site, indicating a novel feature of BMP-1 in the EGF domain. The study clearly outlines the benefit of in-depth characterization of overexpressed proteins to deduce important protein modifications.
Precautions
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Disclaimer
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