Product Name
MYO5A, Blocking Peptide
Full Product Name
MYO5A Immunizing Peptide
Product Synonym Names
MYO5A; myosin VA (heavy chain 12, myoxin); GS1; MYH12; MYO5; MYR12; dilute; myosin V; myosin VA; myosin, heavy polypeptide kinase; myoxin
Product Gene Name
MYO5A blocking peptide
[Similar Products]
MYO5A peptide (MBS427384) is used for blocking the activity of MYO5A antibody (MBS422444)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat, Cow
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of MYO5A blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MYO5A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000250.3
[Other Products]
NCBI Related Accession #
Manufactured in an ISO 9001:2008 Certified Laboratory.NP_001135967.1[Other Products]
NCBI GenBank Nucleotide #
NM_000259.3
[Other Products]
UniProt Secondary Accession #
O60653; Q07902; Q16249; Q9UE30; Q9UE31; A8MZC5[Other Products]
UniProt Related Accession #
Q9Y4I1[Other Products]
Molecular Weight
218,608 Da
NCBI Official Full Name
unconventional myosin-Va isoform 1
NCBI Official Synonym Full Names
myosin VA
NCBI Official Symbol
MYO5A [Similar Products]
NCBI Official Synonym Symbols
GS1; MYO5; MYH12; MYR12
[Similar Products]
NCBI Protein Information
unconventional myosin-Va
UniProt Protein Name
Unconventional myosin-Va
UniProt Synonym Protein Names
Dilute myosin heavy chain, non-muscle; Myosin heavy chain 12; Myosin-12; Myoxin
Protein Family
Unconventional myosin
UniProt Gene Name
MYO5A [Similar Products]
UniProt Synonym Gene Names
MYH12 [Similar Products]
UniProt Entry Name
MYO5A_HUMAN
NCBI Summary for MYO5A
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. [provided by RefSeq, Dec 2008]
UniProt Comments for MYO5A
MYO5A: Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. May also be required for some polarization process involved in dendrite formation. May be a homodimer, which associates with multiple calmodulin or myosin light chains. Binds MLPH and MYRIP. Interacts with RIPL2, the interaction is required for its role in dendrite formation. Detected in melanocytes. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 15q21
Cellular Component: actin filament; actomyosin; cell soma; cytoplasm; cytosol; early endosome; endoplasmic reticulum; filopodium tip; Golgi apparatus; growth cone; intermediate filament; late endosome; lysosome; melanosome; membrane; myosin complex; neuron projection; peroxisome; photoreceptor outer segment; recycling endosome; ruffle; vesicle
Molecular Function: actin binding; ATP binding; calcium ion binding; calmodulin binding; microfilament motor activity; Rab GTPase binding
Biological Process: actin filament-based movement; cellular response to insulin stimulus; ER localization; exocytosis; insulin secretion; locomotion during locomotory behavior; long-chain fatty acid biosynthetic process; melanin biosynthetic process; melanocyte differentiation; melanosome transport; myelination; odontogenesis; post-Golgi vesicle-mediated transport; regulation of inositol-1,4,5-triphosphate receptor activity; secretory granule localization; synapse organization and biogenesis; synaptic transmission; transport; vesicle transport along actin filament; vesicle-mediated transport; visual perception
Disease: Griscelli Syndrome, Type 1
Research Articles on MYO5A
1. These findings reveal a new fast-acting energy conservation strategy halting growth by immobilizing myosin V in a newly described state on selectively stabilized actin cables.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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