Product Name
FBXL19, Polyclonal Antibody
Full Product Name
FBXL19 Antibody, FITC conjugated
Product Synonym Names
F-box/LRR-repeat protein 19; F-box and leucine-rich repeat protein 19; FBXL19; FBL19
Product Gene Name
anti-FBXL19 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
AC135048 Genomic DNA
3D Structure
ModBase 3D Structure for Q6PCT2
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human F-box/LRR-repeat protein 19 protein (4-259AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-136682
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-FBXL19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FBXL19 antibody
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Applications Tested/Suitable for anti-FBXL19 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for FBXL19. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001093254.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001099784.2
[Other Products]
UniProt Primary Accession #
Q6PCT2
[Other Products]
UniProt Secondary Accession #
Q8N789; Q9NT14; A8MT10[Other Products]
UniProt Related Accession #
Q6PCT2[Other Products]
Molecular Weight
72,253 Da
NCBI Official Full Name
F-box/LRR-repeat protein 19 isoform 1
NCBI Official Synonym Full Names
F-box and leucine rich repeat protein 19
NCBI Official Symbol
FBXL19 [Similar Products]
NCBI Official Synonym Symbols
Fbl19; CXXC11; JHDM1C
[Similar Products]
NCBI Protein Information
F-box/LRR-repeat protein 19
UniProt Protein Name
F-box/LRR-repeat protein 19
UniProt Synonym Protein Names
F-box and leucine-rich repeat protein 19
Protein Family
F-box/LRR-repeat protein
UniProt Gene Name
FBXL19 [Similar Products]
UniProt Synonym Gene Names
FBL19 [Similar Products]
UniProt Entry Name
FXL19_HUMAN
NCBI Summary for FBXL19
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Comments for FBXL19
FBXL19: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: SCF ubiquitin ligase complex
Molecular Function: protein binding
Biological Process: proteasomal ubiquitin-dependent protein catabolic process
Research Articles on FBXL19
1. Collectively these data unveil that FBXL19 functions as an antagonist of Rac3 by regulating its stability and regulates the TGFbeta1-induced E-cadherin down-regulation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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