Product Name
Ipaf (NLRC4), Blocking Peptide
Full Product Name
Ipaf Peptide
Product Synonym Names
CLAN; IPAF; CLAN1; CLANA; CLANB; CLANC; CLAND; CARD12; CLR2.1; CLAN; UNQ6189/PRO20215; NLR family CARD domain-containing protein 4; CARD; LRR; and NACHT-containing protein; Clan protein; NLR family, CARD domain containing 4
Product Gene Name
NLRC4 blocking peptide
[Similar Products]
Ipaf peptide (MBS152412) is used for blocking the activity of Ipaf antibody (MBS151519)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NPP4
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
14 amino acids near the center of human Ipaf
Preparation and Storage
Store Ipaf peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of NLRC4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for NLRC4 blocking peptide
Blocking (BL)
Application Notes for NLRC4 blocking peptide
Ipaf peptide is used for blocking the activity of Ipaf antibody.
NCBI/Uniprot data below describe general gene information for NLRC4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_067032
[Other Products]
NCBI GenBank Nucleotide #
NM_021209.4
[Other Products]
UniProt Primary Accession #
Q9NPP4
[Other Products]
UniProt Secondary Accession #
Q96J81; Q96J82; Q96J83; A8K9F8; B2RBQ3; B3KTF0; D6W580[Other Products]
UniProt Related Accession #
Q9NPP4[Other Products]
Molecular Weight
10,646 Da
NCBI Official Full Name
NLR family CARD domain-containing protein 4 isoform a
NCBI Official Synonym Full Names
NLR family, CARD domain containing 4
NCBI Official Symbol
NLRC4 [Similar Products]
NCBI Official Synonym Symbols
CLAN; IPAF; AIFEC; CLAN1; CLANA; CLANB; CLANC; CLAND; FCAS4; CARD12; CLR2.1
[Similar Products]
NCBI Protein Information
NLR family CARD domain-containing protein 4; NOD-like receptor C4; ICE-protease activating factor; CARD, LRR, and NACHT-containing protein; caspase recruitment domain family, member 12; caspase recruitment domain-containing protein 12; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
UniProt Protein Name
NLR family CARD domain-containing protein 4
UniProt Synonym Protein Names
CARD, LRR, and NACHT-containing protein; Clan protein; Caspase recruitment domain-containing protein 12; Ice protease-activating factor; Ipaf
Protein Family
NLR family CARD domain-containing protein
UniProt Gene Name
NLRC4 [Similar Products]
UniProt Synonym Gene Names
CARD12; CLAN; CLAN1; IPAF; Clan protein; Ipaf [Similar Products]
UniProt Entry Name
NLRC4_HUMAN
NCBI Summary for NLRC4
This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
UniProt Comments for NLRC4
NLRC4: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 2p22.3
Cellular Component: spindle microtubule; cytoplasm; intracellular; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; magnesium ion binding; ubiquitin-protein ligase activity; cysteine protease inhibitor activity; ATP binding
Biological Process: caspase activation; detection of bacterium; positive regulation of apoptosis; regulation of signal transduction; protein ubiquitination; activation of NF-kappaB transcription factor; defense response to bacterium; regulation of neuron apoptosis; innate immune response; interleukin-1 beta secretion; inflammatory response; activation of innate immune response; protein homooligomerization; negative regulation of apoptosis
Disease: Autoinflammation With Infantile Enterocolitis; Familial Cold Autoinflammatory Syndrome 4
Research Articles on NLRC4
1. Data show that the disease was caused by a de novo gain-of-function mutation in NLR family CARD domain containing 4 (NLRC4) encoding a p.Val341Ala substitution.
Precautions
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Disclaimer
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