Full Product Name
GRK1 antibody - middle region
Product Gene Name
anti-GRK1 antibody
[Similar Products]
Product Synonym Gene Name
GPRK1; RHOK; RK[Similar Products]
Antibody/Peptide Pairs
GRK1 peptide (MBS3239439) is used for blocking the activity of GRK1 antibody (MBS3214502)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: NKELKHRIIS EPVKYPDKFS QASKDFCEAL LEKDPEKRLG FRDETCDKLR
3D Structure
ModBase 3D Structure for Q15835
Species Reactivity
Cow, Dog, Horse, Human, Mouse, Pig, Rat, Zebrafish
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 92%; Dog: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 79%; Rat: 93%; Zebrafish: 83%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human GRK1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-GRK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GRK1 antibody
This is a rabbit polyclonal antibody against GRK1. It was validated on Western Blot
Target Description: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2).
Product Categories/Family for anti-GRK1 antibody
Polyclonal; Signaling Intermediate; Cell Adhesion; GPCR; Phosphorylation;
Applications Tested/Suitable for anti-GRK1 antibody
Western Blot (WB)
Western Blot (WB) of anti-GRK1 antibody
WB Suggested Anti-GRK1 Antibody
Titration: 1.0 ug/ml
Positive Control: Jurkat Whole Cell
NCBI/Uniprot data below describe general gene information for GRK1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002920
[Other Products]
NCBI GenBank Nucleotide #
NM_002929
[Other Products]
UniProt Primary Accession #
Q15835
[Other Products]
UniProt Related Accession #
Q15835[Other Products]
NCBI Official Full Name
rhodopsin kinase
NCBI Official Synonym Full Names
G protein-coupled receptor kinase 1
NCBI Official Symbol
GRK1 [Similar Products]
NCBI Official Synonym Symbols
RK; RHOK; GPRK1
[Similar Products]
NCBI Protein Information
rhodopsin kinase
UniProt Protein Name
Rhodopsin kinase
UniProt Synonym Protein Names
G protein-coupled receptor kinase 1
UniProt Gene Name
GRK1 [Similar Products]
UniProt Synonym Gene Names
RHOK; RK [Similar Products]
UniProt Entry Name
RK_HUMAN
NCBI Summary for GRK1
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]
UniProt Comments for GRK1
GRK1: a Ser/Thr of the GRK family. Phosphorylates and inactivates photon-activated rhodopsin. LOF mutations lead to type 2 Oguchi disease, a form of night blindness. A link between RHOK and retinitis pigmentosa is now thought to be unlikely
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, AGC; EC 2.7.11.14; AGC group; GRK family; GRK subfamily
Chromosomal Location of Human Ortholog: 13q34
Molecular Function: G-protein coupled receptor kinase activity; rhodopsin kinase activity; ATP binding; protein kinase activity
Biological Process: rhodopsin mediated signaling; post-embryonic retina morphogenesis in camera-type eye; phototransduction, visible light; regulation of rhodopsin mediated signaling; visual perception; protein amino acid autophosphorylation; photoreceptor cell morphogenesis; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of phosphorylation; negative regulation of apoptosis
Disease: Oguchi Disease 2
Research Articles on GRK1
1. In conclusion, in the present report, a novel missense mutation in GRK1 gene in homozygous state was reported in an Italian patient affected with Oguchi disease.
Precautions
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Disclaimer
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