E3 ubiquitin-protein ligase TRIM37, ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

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Small volumes of TRIM37 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2604115 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the E3 ubiquitin-protein ligase TRIM37, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TRIM37. The ELISA analytical biochemical technique of the MBS2604115 kit is based on TRIM37 antibody-TRIM37 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TRIM37 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TRIM37. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

103,941 Da

tripartite motif containing 37

E3 ubiquitin-protein ligase TRIM37

E3 ubiquitin-protein ligase TRIM37

TRI37_HUMAN

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016]

TRIM37: E3 ubiquitin-protein ligase. Defects in TRIM37 are the cause of mulibrey nanism (MUL); also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; EC 6.3.2.-; Ubiquitin ligase; Oncoprotein; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: cytoplasm; cytosol; ESC/E(Z) complex; perinuclear region of cytoplasm; peroxisome

Molecular Function: chromatin binding; ligase activity; protein binding; protein homodimerization activity; tumor necrosis factor receptor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: activation of NF-kappaB transcription factor; inhibition of NF-kappaB transcription factor; negative regulation of centriole replication; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; protein autoubiquitination; transcription, DNA-dependent

Disease: Mulibrey Nanism

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