Product Name
Adenosylhomocysteinase (AHCY), Polyclonal Antibody
Full Product Name
Rabbit anti-human Adenosylhomocysteinase polyclonal Antibody, Biotin conjugated
Product Synonym Names
S-adenosyl-L-homocysteine hydrolase; SAHH
Product Gene Name
anti-AHCY antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P23526
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunogen
Recombinant human Adenosylhomocysteinase protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-55758 / sc-55759
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-AHCY antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AHCY antibody
Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
Applications Tested/Suitable for anti-AHCY antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for AHCY. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000678.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000687.2
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UniProt Primary Accession #
P23526
[Other Products]
UniProt Secondary Accession #
Q96A36; A8K307; B3KUN3; E1P5P2; F5H737[Other Products]
UniProt Related Accession #
P23526[Other Products]
Molecular Weight
44,659 Da
NCBI Official Full Name
adenosylhomocysteinase isoform 1
NCBI Official Synonym Full Names
adenosylhomocysteinase
NCBI Official Symbol
AHCY [Similar Products]
NCBI Official Synonym Symbols
SAHH; adoHcyase
[Similar Products]
NCBI Protein Information
adenosylhomocysteinase
UniProt Protein Name
Adenosylhomocysteinase
UniProt Synonym Protein Names
S-adenosyl-L-homocysteine hydrolase
Protein Family
Adenosylhomocysteinase
UniProt Gene Name
AHCY [Similar Products]
UniProt Synonym Gene Names
SAHH; AdoHcyase [Similar Products]
UniProt Entry Name
SAHH_HUMAN
NCBI Summary for AHCY
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
UniProt Comments for AHCY
SAHH: Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Defects in AHCY are the cause of hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD). A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy. Belongs to the adenosylhomocysteinase family.
Protein type: EC 3.3.1.1; Amino Acid Metabolism - cysteine and methionine; Other Amino Acids Metabolism - selenoamino acid; Hydrolase
Chromosomal Location of Human Ortholog: 20q11.22
Cellular Component: cytoplasm; cytosol; melanosome; neuron projection; nucleus
Molecular Function: adenosylhomocysteinase activity; adenyl nucleotide binding; identical protein binding; NAD binding; protein binding
Biological Process: chronic inflammatory response to antigenic stimulus; circadian sleep/wake cycle; methylation; one-carbon compound metabolic process; response to hypoxia; response to nutrient; S-adenosylhomocysteine catabolic process; S-adenosylmethionine cycle; selenium metabolic process; sulfur amino acid metabolic process; xenobiotic metabolic process
Disease: Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency
Research Articles on AHCY
1. S-adenosylhomocysteine hydrolase is regulated by lysine acetylation
Precautions
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Disclaimer
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