SLC40A1, Polyclonal Antibody

Anti -SLC40A1 (Solute Carrier Family 40 Member 1, Ferroportin-1, Iron-regulated Transporter 1, FPN1, IREG1, SLC11A3, MSTP079)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 2; NC_000002.11 (190425316..190448478, complement). Location: 2q32

Polyclonal

IgG

Rabbit

Recognizes human SLC40A1.

Affinity Purified
Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-SLC40A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

SLC40A1 is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4).

Antibodies; Abs to Ion Channel

Western Blot (WB)

Suitable for use in Western Blot.

62,542 Da[Similar Products]

solute carrier family 40 (iron-regulated transporter), member 1

solute carrier family 40 member 1; iron regulated gene 1; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3

Solute carrier family 40 member 1

FPN1; IREG1; SLC11A3  [Similar Products]

S40A1_HUMAN

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

SLC40A1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4). HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.

Protein type: Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: multivesicular body; synaptic vesicle; basolateral plasma membrane; integral to plasma membrane; cytoplasm; integral to membrane; plasma membrane; intracellular

Molecular Function: iron ion transmembrane transporter activity; protein binding

Biological Process: anatomical structure morphogenesis; cellular iron ion homeostasis; positive regulation of transcription from RNA polymerase II promoter; lymphocyte homeostasis; transmembrane transport; negative regulation of apoptosis

Disease: Hemochromatosis, Type 4

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