SLC40A1, Polyclonal Antibody

SLC40A1; solute carrier family 40 (iron-regulated transporter), member 1; FPN1; HFE4; IREG1; MST079; MTP1; SLC11A3; iron regulated gene 1; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), memb; SLC40A1 antibody; solute carrier family 40 (iron-regulated transporter); member 1 antibody; FPN1 antibody; HFE4 antibody; IREG1 antibody; MST079 antibody; MTP1 antibody; SLC11A3 antibody; iron regulated gene 1 antibody; putative ferroportin 1 variant IIIB antibody; solute carrier family 11 (proton-coupled divalent metal ion transporters); member 3 antibody; solute carrier family 40 member 1 antibody; SLC40A1 (aa245-259)

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-SLC40A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 55kDa band observed in Human Breast cancer lysates (calculated MW of 62.5kDa according to NP_055400.1). Recommended concentration: 1-3ug/ml.

(1ug/ml) staining of Breast cancer lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

62,542 Da

solute carrier family 40 member 1

solute carrier family 40 member 1

Solute carrier family 40 member 1

FPN1; IREG1; SLC11A3  [Similar Products]

S40A1_HUMAN

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

SLC40A1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4). HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.

Protein type: Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: basolateral plasma membrane; cytoplasm; integral to membrane; integral to plasma membrane; intracellular; multivesicular body; plasma membrane; synaptic vesicle

Molecular Function: ferrous iron transmembrane transporter activity; iron ion transmembrane transporter activity; peptide hormone binding; protein binding; receptor activity

Biological Process: cellular iron ion homeostasis; lymphocyte homeostasis; negative regulation of apoptosis; positive regulation of transcription from RNA polymerase II promoter

Disease: Hemochromatosis, Type 4

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