ADP/ATP translocase 1, ELISA Kit

ADP/ATP translocase 1; ADP; ATP carrier protein 1; ADP; ATP carrier protein; heart/skeletal muscle isoform T1; Adenine nucleotide translocator 1; ANT 1; Solute carrier family 25 member

For Research Use Only. Not for use in diagnostic procedures.

Store at 4 degree C

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Small volumes of SLC25A4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9427409 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ADP/ATP translocase 1 (SLC25A4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SLC25A4. The ELISA analytical biochemical technique of the MBS9427409 kit is based on SLC25A4 antibody-SLC25A4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SLC25A4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SLC25A4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

33,064 Da

solute carrier family 25 member 4

ADP/ATP translocase 1

ADP/ATP translocase 1

ANT1; ANT 1  [Similar Products]

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013]

SLC25A4: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. Defects in SLC25A4 are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 2 (PEOA2). Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged- red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism. Belongs to the mitochondrial carrier family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: integral to plasma membrane; mitochondrial inner membrane; mitochondrion; nucleus

Molecular Function: adenine transmembrane transporter activity; ATP:ADP antiporter activity; protein binding

Biological Process: ADP transport; generation of precursor metabolites and energy; mitochondrial genome maintenance; regulation of insulin secretion; regulation of mitochondrial membrane permeability; transport

Disease: Mitochondrial Dna Depletion Syndrome 12 (cardiomyopathic Type); Mitochondrial Dna Depletion Syndrome 12a (cardiomyopathic Type), Autosomal Dominant; Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 2

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