Caveolin 2, Antibody

For Research Use Only. Not for use in diagnostic procedures.

Rabbit

1.0mg/ml (lot specific)

Small volumes of anti-CAV2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB)

12,780 Da[Similar Products]

caveolin 2

caveolin-2

Caveolin-2

The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]

Caveolin-2: a scaffolding protein. A component of caveolae, small invaginations of the plasma membrane found in most cell types. Involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-2 may function as an accessory protein in conjunction with caveolin-1. Two splice-variant isoforms have been observed.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q31.2

Cellular Component: caveola; cytoplasmic vesicle; extrinsic to internal side of plasma membrane; focal adhesion; Golgi apparatus; integral to plasma membrane; intracellular; lipid raft; perinuclear region of cytoplasm; plasma membrane; protein complex; transport vesicle

Molecular Function: protein binding; protein homodimerization activity

Biological Process: endoplasmic reticulum organization and biogenesis; insulin receptor signaling pathway; mitochondrion organization and biogenesis; negative regulation of endothelial cell proliferation; positive regulation of dopamine receptor signaling pathway; positive regulation of GTPase activity; positive regulation of MAPKKK cascade; receptor mediated endocytosis of virus by host; regulation of mitosis; skeletal muscle fiber development; vesicle docking; vesicle fusion; vesicle organization and biogenesis

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