Lactoferrin, Polyclonal Antibody

Rabbit Antibody to Human Lactoferrin

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 3; NC_000003.11 (46477496..46506395, complement). Location: 3p21.31

Polyclonal

Rabbit

Lactoferrin
Based on immunoelectrophoresis, the antibody reacts with human lactoferrin found in human milk. No antibody was detected against other milk or serum proteins, but antibodies may cross-react with lactoferrin from other species.

Isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads

HRP, Lyophilized
Reconstitute with 1.5ml distilled water. Centrifuge product if it is not completely clear after standing for 1-2 hours at room temperature. To judge clarity, draw product into a pasteur pipette.

0.8mg/ml (prior to lyophilization) (lot specific)

Store lyophilized product at 2 to 8 degree C. After reconstitution, aliquot and store at -70 degree C or below. Prepare working dilution only prior to immediate use. For long-term storage after reconstitution, we suggest the addition of an equal volume of

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-LTF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Polyclonal Antibodies to Proteins and Bioactive Peptides

A dilution range of 1:500 - 1:5,000 is suggested for immunohistochemistry on tissue sections, 1:5,000 - 1:100,000 for ELISA and Western blotting with chromogenic substrates and 1:10,000 - 1:200,000 for Western blotting with ECL substrates. Each laboratory

78,182 Da[Similar Products]

lactotransferrin

lactotransferrin; talalactoferrin; OTTHUMP00000209779; OTTHUMP00000209780; OTTHUMP00000209781; neutrophil lactoferrin; growth-inhibiting protein 12

Lactotransferrin

LF  [Similar Products]

TRFL_HUMAN

This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Function: Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. Ref.21Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration. Ref.21Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors. Ref.21The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Ref.21

Catalytic activity: Preferential at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin.

Subunit structure: Monomer.

Subcellular location: Secreted.

Sequence similarities: Belongs to the transferrin family.Contains 2 transferrin-like domains.

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