Product Name
Presenilin 2 (PSEN2), Monoclonal Antibody
Full Product Name
Presenilin 2 (N term) Mouse Monoclonal Antibody (APS26)
Product Synonym Names
PS-2; AD3LP; AD5; E5-1; STM-2
Product Gene Name
anti-PSEN2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P49810
Species Reactivity
Mouse, Rat, Human
Specificity
The antibody recognizes the N-terminal region of Presenilin 2 with no crossreactivity observed with Presenilin 1.
Form/Format
Lyophilized protein free tissue culture supernatant
Preparation and Storage
Lyophilized antibody can be kept at 4 degree C for up to 3 months and should be kept at-20 degree C for long-term storage.
To avoid freeze-thaw cycles, reconstituted antibody should be aliquoted before freezing for short-term storage (-20 degree C) or for long-term storage (-80 degree C).
For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-PSEN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PSEN2 antibody
Presenilin is an integral membrane protein ubiquitously expressed in the brain; it is mainly expressed in neurons where it is localized in the endoplasmic reticulum. Mutations in the presenilin proteins (PSEN1; PSEN2) are linked to an inherited form of Alzheimer's disease in some patients by increasing the production of the longer form of amyloid-beta. Presenilins are thought to affect gamma-secretase by regulating amyloid precursor protein (APP) processing and cleavage of the Notch receptor.
Applications Tested/Suitable for anti-PSEN2 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-PSEN2 antibody
If reconstituted in 250muL: ELISA: 1:200; WB: 1:100; IF: 1:1300; IHC: 1:1300
NCBI/Uniprot data below describe general gene information for PSEN2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036618.2
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NCBI GenBank Nucleotide #
NM_012486.2
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UniProt Primary Accession #
P49810
[Other Products]
UniProt Secondary Accession #
Q96P32; A8K8D4; B1AP21[Other Products]
UniProt Related Accession #
P49810[Other Products]
Molecular Weight
46,387 Da
NCBI Official Full Name
presenilin-2 isoform 2
NCBI Official Synonym Full Names
presenilin 2
NCBI Official Symbol
PSEN2 [Similar Products]
NCBI Official Synonym Symbols
AD4; PS2; AD3L; STM2; CMD1V
[Similar Products]
NCBI Protein Information
presenilin-2
UniProt Protein Name
Presenilin-2
UniProt Synonym Protein Names
AD3LP; AD5; E5-1; STM-2
Protein Family
Presenilin
UniProt Gene Name
PSEN2 [Similar Products]
UniProt Synonym Gene Names
AD4; PS2; PSNL2; STM2; PS-2 [Similar Products]
NCBI Summary for PSEN2
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for PSEN2
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
Product References and Citations for anti-PSEN2 antibody
1. Diehlmann A-Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies.
Research Articles on PSEN2
1. Determined whether a pathogenic mutation in the PSEN2 gene in a Korean patient was associated with early onset Alzheimer's disease. Findings revealed that the p.His169Asn might be an important residue in PSEN2, which may alter the functions of PSEN2, suggesting its potential involvement with AD phenotype.
Precautions
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