Collagen Type XVII, aa507-548, Polyclonal Antibody

Anti -Collagen Type XVII, aa507-548 (BP180, Collagen type XVII alpha 1, COL17A1, 180kD bullous pemphigoid antigen 2, BA16H23.2, BPAG2, Bullous pemphigoid antigen 2, Collagen alpha-1(XVII) chain, FLJ60881, KIAA0204, LAD-1)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 10; NC_000010.10 (105791046..105845638, complement). Location: 10q24.3

Polyclonal

IgG

Rabbit

Recogizes human Type XVII Collagen.

Affinity Purified
Purified Protein G affinity chromatography

Supplied as a lyophilized powder in PBS, pH 7.2. Reconstitute in ddH2O.

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-COL17A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to Collagen

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Suitable for use in ELISA, Immunocytochemistry, Immunohistochemistry and Western Blot.
Dilution: ELISA: 1:5000
Western Blot: 1:500
Immunocytochemistry (Frozen): 1:100

150,419 Da[Similar Products]

collagen, type XVII, alpha 1

collagen alpha-1(XVII) chain; collagen alpha-1(XVII) chain; OTTHUMP00000020422; OTTHUMP00000020424; alpha 1 type XVII collagen; collagen XVII, alpha-1 polypeptide; 180 kDa bullous pemphigoid antigen 2; bullous pemphigoid antigen 2 (180kD); bA16H23.2 (collagen, type XVII, alpha 1 (BP180))

Collagen alpha-1(XVII) chain

BP180; BPAG2  [Similar Products]

COHA1_HUMAN

This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq]

COL17A1: May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. Defects in COL17A1 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). GABEB is a non- lethal, ***** form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q24.3

Cellular Component: collagen; hemidesmosome; integral to plasma membrane; endoplasmic reticulum lumen; plasma membrane; extracellular region; basement membrane; intercellular junction

Molecular Function: protein binding

Biological Process: collagen catabolic process; extracellular matrix disassembly; epidermis development; extracellular matrix organization and biogenesis; hemidesmosome assembly; cell-matrix adhesion

Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type

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