Product Name
AK1, cDNA Clone
Full Product Name
AK1 cDNA Clone
Product Gene Name
AK1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggaagaga agctgaagaa aaccaatatc atctttgtgg tgggtgggcc tggctcaggg aagggcaccc agtgtgagaa gatcgtgcag aagtatggct acacccacct ctccaccggg gacctcctgc ggtccgaggt cagctcaggc tcggccaggg gcaagaagct gtcggaaatc atggagaagg ggcagctggt tccactggag acagtgttgg acatgctccg ggatgccatg gtggccaaag tcaatacttc caaaggcttc ctgattgatg gctacccgcg ggaggtgcag caaggagaag agtttgagcg acggattgga cagcccacac tgctgctgta tgtggacgca ggccctgaga ccatgaccca gcggctcttg aaacgtggag agaccagcgg gcgtgtggac gacaatgagg agaccatcaa aaagcggctg gagacctatt acaaggccac agaacccgtc atcgccttct atgagaaacg tggcattgtg cgcaaggtca acgctgaggg ctccgtggac agtgtcttct cccaggtctg cacccacctg gacgccctaa agtag
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of AK1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for AK1. It may not necessarily be applicable to this product.
NCBI Accession #
BC001116
[Other Products]
UniProt Secondary Accession #
Q9BVK9; Q9UQC7[Other Products]
UniProt Related Accession #
P00568[Other Products]
Molecular Weight
21,635 Da
NCBI Official Full Name
Homo sapiens adenylate kinase 1, mRNA
NCBI Official Synonym Full Names
adenylate kinase 1
NCBI Official Symbol
AK1 [Similar Products]
NCBI Official Synonym Symbols
HTL-S-58j
[Similar Products]
NCBI Protein Information
adenylate kinase isoenzyme 1
UniProt Protein Name
Adenylate kinase isoenzyme 1
UniProt Synonym Protein Names
ATP-AMP transphosphorylase 1
Protein Family
Adenylate kinase
UniProt Gene Name
AK1 [Similar Products]
UniProt Synonym Gene Names
AK 1 [Similar Products]
UniProt Entry Name
KAD1_HUMAN
NCBI Summary for AK1
This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
UniProt Comments for AK1
AK1: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD). Belongs to the adenylate kinase family.
Protein type: Nucleotide Metabolism - purine; Kinase, other; EC 2.7.4.6; EC 2.7.4.3
Chromosomal Location of Human Ortholog: 9q34.1
Cellular Component: cytoplasm; cytosol
Molecular Function: adenylate kinase activity; nucleoside diphosphate kinase activity
Biological Process: nucleobase, nucleoside and nucleotide interconversion; nucleoside diphosphate phosphorylation; nucleoside triphosphate biosynthetic process
Disease: Adenylate Kinase Deficiency, Hemolytic Anemia Due To
Research Articles on AK1
1. Studies indicate that the preferred substrate and phosphate donor of all adenylate kinases are AMP and ATP respectively.
Precautions
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Disclaimer
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