Full Product Name
BMP-1 Polyclonal Antibody
Product Synonym Names
Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP)
Product Gene Name
anti-BMP-1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P13497
Species Reactivity
Human, Mouse, Rat
Specificity
The antibody detects endogenous BMP-1
Purity/Purification
Affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Form/Format
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Concentration
1 mg/ml (lot specific)
Immunogen
Synthetic peptide from human protein at AA range: 131-180
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-BMP-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-BMP-1 antibody
Total protein Ab
Applications Tested/Suitable for anti-BMP-1 antibody
Immunohistochemistry (IHC)
Application Notes for anti-BMP-1 antibody
IHC: 1:50-300
Immunohistochemistry (IHC) of anti-BMP-1 antibody
Immunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:200
Immunohistochemistry (IHC) of anti-BMP-1 antibody
Immunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:200
NCBI/Uniprot data below describe general gene information for BMP-1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001190.1
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NCBI GenBank Nucleotide #
NM_001199.3
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UniProt Primary Accession #
P13497
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UniProt Secondary Accession #
Q13292; Q13872; Q14874; Q99421; Q99422; Q99423; Q9UL38; A8K6F5; B2RN46; D3DSR0[Other Products]
UniProt Related Accession #
P13497[Other Products]
Molecular Weight
92,655 Da
NCBI Official Full Name
bone morphogenetic protein 1 isoform 1
NCBI Official Synonym Full Names
bone morphogenetic protein 1
NCBI Official Symbol
BMP1 [Similar Products]
NCBI Official Synonym Symbols
PCP; TLD; OI13; PCP2; PCOLC
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NCBI Protein Information
bone morphogenetic protein 1
UniProt Protein Name
Bone morphogenetic protein 1
UniProt Synonym Protein Names
Mammalian tolloid protein; mTld; Procollagen C-proteinase; PCP
UniProt Gene Name
BMP1 [Similar Products]
UniProt Synonym Gene Names
PCOLC; BMP-1; mTld; PCP [Similar Products]
NCBI Summary for BMP-1
This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]
UniProt Comments for BMP-1
BMP1: Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Defects in BMP1 are a cause of autosomal recessive osteogenesis imperfecta (AR-OI). A connective tissue disorder characterized by bone fragility, progressively deforming bones, bowing of limbs due to multiple fractures, very short stature, a triangular face, severe scoliosis, and grayish sclera. AR-OI due to BMP1 mutations belongs to the group of osteogenesis imperfecta type III in the Sillence classification. Belongs to the peptidase M12A family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine; EC 3.4.24.19; Protease
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: extracellular region
Molecular Function: metalloendopeptidase activity; peptidase activity; protein binding; serine-type endopeptidase activity
Biological Process: cartilage condensation; extracellular matrix disassembly; multicellular organismal development; proteolysis
Disease: Osteogenesis Imperfecta, Type Xiii
Research Articles on BMP-1
1. a previously unknown O-glycosylation site and Asn-hydroxylation site, indicating a novel feature of BMP-1 in the EGF domain. The study clearly outlines the benefit of in-depth characterization of overexpressed proteins to deduce important protein modifications.
Precautions
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Disclaimer
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