Product Name
active+pro Caspase 3 (CASP-3), Monoclonal Antibody
Full Product Name
active+pro Caspase 3
Product Synonym Names
Caspase-3; Apopain; Cysteine protease CPP32; Protein Yama; SREBP cleavage activity 1
Product Gene Name
anti-CASP-3 antibody
[Similar Products]
Product Synonym Gene Name
CPP-32; SCA-1; CASP3[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P42574
Purity/Purification
ProA affinity purified
Immunogen
Recombinant Protein
Storage Buffer
1*TBS (pH7.4), 1% BSA, 40% Glycerol.
Preservative
0.05% Sodium Azide.
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-CASP-3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CASP-3 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
NCBI/Uniprot data below describe general gene information for CASP-3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004337.2
[Other Products]
NCBI GenBank Nucleotide #
NM_004346.3
[Other Products]
UniProt Primary Accession #
P42574
[Other Products]
UniProt Secondary Accession #
Q96AN1; Q96KP2; A8K5M2; D3DP53[Other Products]
UniProt Related Accession #
P42574[Other Products]
Molecular Weight
31,608 Da
NCBI Official Full Name
caspase-3 isoform a preproprotein
NCBI Official Synonym Full Names
caspase 3
NCBI Official Symbol
CASP3 [Similar Products]
NCBI Official Synonym Symbols
CPP32; SCA-1; CPP32B
[Similar Products]
NCBI Protein Information
caspase-3
UniProt Protein Name
Caspase-3
UniProt Synonym Protein Names
Apopain; Cysteine protease CPP32; CPP-32
UniProt Gene Name
CASP3 [Similar Products]
UniProt Synonym Gene Names
CPP32; CASP-3; CPP-32; SCA-1 [Similar Products]
NCBI Summary for CASP-3
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
UniProt Comments for CASP-3
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Research Articles on CASP-3
1. The phosphorylation level of p38 was upregulated by MA1 treatment, and the inhibitor of p38, SB203580, attenuated the MA1-induced p38 phosphorylation as well as caspase3 and PARP activation. These results indicate that MA1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through the stimulation of the p38 signaling pathway
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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