Full Product Name
CHGA Polyclonal Antibody
Product Synonym Names
CGA
Product Gene Name
anti-CHGA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purification
Concentration
2.2mg/ml (lot specific)
Immunogen
Synthetic peptide of human CHGA
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CHGA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CHGA antibody
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three
biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene.
Applications Tested/Suitable for anti-CHGA antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CHGA antibody
ELISA: 1:1000-2000
IHC: 1:25-100
WB: 1:200-1000
Immunohistochemistry (IHC) of anti-CHGA antibody
Immunohistochemistry of paraffin-embedded Human thyroid cancer using CHGA Polyclonal Antibody at dilution of 1/35
Immunohistochemistry (IHC) of anti-CHGA antibody
Immunohistochemistry of paraffin-embedded Human esophagus cancer using CHGA Polyclonal Antibody at dilution of 1/35
NCBI/Uniprot data below describe general gene information for CHGA. It may not necessarily be applicable to this product.
UniProt Secondary Accession #
Q53FA8; Q6NR84; Q96E84; Q96GL7; Q9BQB5; B2R9E9[Other Products]
UniProt Related Accession #
P10645[Other Products]
NCBI Official Full Name
CHGA protein, partial
NCBI Official Synonym Full Names
chromogranin A
NCBI Official Symbol
CHGA [Similar Products]
NCBI Official Synonym Symbols
CGA
[Similar Products]
NCBI Protein Information
chromogranin-A
UniProt Protein Name
Chromogranin-A
UniProt Synonym Protein Names
SL21
Protein Family
Chromogranin
UniProt Gene Name
CHGA [Similar Products]
UniProt Synonym Gene Names
CgA; SP-I [Similar Products]
UniProt Entry Name
CMGA_HUMAN
NCBI Summary for CHGA
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
UniProt Comments for CHGA
CHGA: a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells and is a precursor to multiple biologically active peptides including vasostatin, pancreastatin, and chromostatin. Binds calcium with a low-affinity. Vasostatin negatively regulates angiogenesis and has antibacterial activity against some Gram-positive bacteria. Pancreastatin inhibits glucose induced insulin release from the pancreas. Chromostatin inhibits catecholamine release from chromaffin cells.
Protein type: Cell adhesion; Secreted; Secreted, signal peptide; Vesicle
Chromosomal Location of Human Ortholog: 14q32
Cellular Component: extracellular space; perinuclear region of cytoplasm; secretory granule
Biological Process: defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; mast cell activation; mast cell chemotaxis; mast cell cytokine production; mast cell degranulation; negative regulation of catecholamine secretion; negative regulation of vasodilation; organelle organization and biogenesis; positive regulation of cAMP metabolic process; regulation of blood pressure; regulation of the force of heart contraction
Research Articles on CHGA
1. Data indicate that measurement of chromogranin A (CgA) alone is sufficient in the management of patients with neuroendocrine tumours (NETs) and that routine additional measurement of chromogranin B (CgB) provides little added value.
Precautions
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Disclaimer
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