Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (NOS1AP)

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

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Small volumes of NOS1AP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS7247047 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (NOS1AP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NOS1AP. The ELISA analytical biochemical technique of the MBS7247047 kit is based on NOS1AP antibody-NOS1AP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NOS1AP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NOS1AP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Neurobiology

55,569 Da

nitric oxide synthase 1 (neuronal) adaptor protein

carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; nitric oxide synthase 1 adaptor protein; C-terminal PDZ ligand of neuronal nitric oxide synthase protein; C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON); ligand of neuronal nitric oxide synthase with carboxyl-terminal PDZ domain

Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

CAPON; KIAA0464  [Similar Products]

CAPON_HUMAN

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]

NOS1AP: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: nuclear membrane; sarcoplasmic reticulum membrane; mitochondrion; perinuclear region of cytoplasm; T-tubule; caveola; Z disc; nucleus; cytosol; sarcolemma

Molecular Function: nitric-oxide synthase binding

Biological Process: regulation of apoptosis; regulation of nitric oxide biosynthetic process; positive regulation of nitric oxide biosynthetic process; chemical signal regulation of heart rate; positive regulation of nitric-oxide synthase activity; regulation of nitric-oxide synthase activity

Disease: Qt Interval, Variation In

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