Full Product Name
Anti-SATB2 Rabbit pAb
Product Synonym Names
GLSS; SATB family member 2; SATB homeobox 2; SATB2; Special AT rich sequence binding protein 2
Product Gene Name
anti-SATB2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UPW6
Species Reactivity
Human, Mouse, Rat
Specificity
SATB2 Antibody detects endogenous levels of total SATB2
Purity/Purification
Affinity Chromatography
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human SATB2
Subcellular Location
Nucleus matrix
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Other Notes
Small volumes of anti-SATB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SATB2 antibody
Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers.
Applications Tested/Suitable for anti-SATB2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-SATB2 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
ICC/IF: 1:50-1:200
Western Blot (WB) of anti-SATB2 antibody
Western blot analysis of SATB2 expression in Saos-2 cell lysate.
Immunohistochemistry (IHC) of anti-SATB2 antibody
Immunohistochemical analysis of paraffin-embedded human stomach cancer, using SATB2 Antibody.
Immunofluorescence (IF) of anti-SATB2 antibody
Immunofluorescent analysis of SH-SY5Y cells, using SATB2 Antibody.
NCBI/Uniprot data below describe general gene information for SATB2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001165980.1
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NCBI GenBank Nucleotide #
NM_001172509.1
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UniProt Primary Accession #
Q9UPW6
[Other Products]
UniProt Secondary Accession #
Q3ZB87; Q4V763; A8K5Z8[Other Products]
UniProt Related Accession #
Q9UPW6[Other Products]
NCBI Official Full Name
DNA-binding protein SATB2
NCBI Official Synonym Full Names
SATB homeobox 2
NCBI Official Symbol
SATB2 [Similar Products]
NCBI Official Synonym Symbols
GLSS
[Similar Products]
NCBI Protein Information
DNA-binding protein SATB2
UniProt Protein Name
DNA-binding protein SATB2
UniProt Synonym Protein Names
Special AT-rich sequence-binding protein 2
Protein Family
DNA-binding protein
UniProt Gene Name
SATB2 [Similar Products]
UniProt Synonym Gene Names
KIAA1034 [Similar Products]
NCBI Summary for SATB2
This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010]
UniProt Comments for SATB2
Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.
Research Articles on SATB2
1. We describe the phenotype and genotype of 12 individuals with 10 unique (de novo in 11 of 11 tested) pathogenic variants (1 splice site, 5 frameshift, 3 nonsense, and 2 missense) in SATB2 and review all cases reported in the published literature caused by point alterations thus far
Precautions
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Disclaimer
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