Product Name
phosphatidylinositol glycan anchor biosynthesis, class M (PIGM), Polyclonal Antibody
Full Product Name
Rabbit anti-human phosphatidylinositol glycan anchor biosynthesis, class M polyclonal Antibody
Product Synonym Names
phosphatidylinositol glycan anchor biosynthesis; class M; PIGM; GPI-MT-I; MGC29896
Product Gene Name
anti-PIGM antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-PIGM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PIGM antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for PIGM. It may not necessarily be applicable to this product.
NCBI Accession #
AAH19865.1
[Other Products]
UniProt Related Accession #
Q9H3S5[Other Products]
Molecular Weight
49,460 Da[Similar Products]
NCBI Official Full Name
Phosphatidylinositol glycan anchor biosynthesis, class M
NCBI Official Synonym Full Names
phosphatidylinositol glycan anchor biosynthesis, class M
NCBI Official Symbol
PIGM [Similar Products]
NCBI Official Synonym Symbols
GPI-MT-I
[Similar Products]
NCBI Protein Information
GPI mannosyltransferase 1; GPI mannosyltransferase I; PIG-M mannosyltransferase; DPM:GlcN-(acyl-)PI mannosyltransferase; dol-P-Man dependent GPI mannosyltransferase; phosphatidylinositol-glycan biosynthesis class M protein
UniProt Protein Name
GPI mannosyltransferase 1
UniProt Synonym Protein Names
GPI mannosyltransferase I; GPI-MT-I; Phosphatidylinositol-glycan biosynthesis class M protein; PIG-M
Protein Family
Probable NAD(P)H nitroreductase
UniProt Gene Name
PIGM [Similar Products]
UniProt Synonym Gene Names
GPI-MT-I; PIG-M [Similar Products]
UniProt Entry Name
PIGM_HUMAN
NCBI Summary for PIGM
This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
UniProt Comments for PIGM
PIGM: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Defects in PIGM are the cause of glycosylphosphatidylinositol deficiency (GPID). GPID is an autosomal recessive trait that results in a propensity to venous thrombosis and seizures. Deficiency is due to a point mutation in the regulatory sequences of PIGM that disrupts binding of the transcription factor SP1 to its cognate promoter motif, leading to a strong reduction of expression. Belongs to the PIGM family.
Protein type: Membrane protein, multi-pass; EC 2.4.1.-; Transferase; Membrane protein, integral; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis
Chromosomal Location of Human Ortholog: 1q23.2
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: mannosyltransferase activity
Biological Process: cellular protein metabolic process; preassembly of GPI anchor in ER membrane; C-terminal protein lipidation; post-translational protein modification
Disease: Glycosylphosphatidylinositol Deficiency
Research Articles on PIGM
1. Studies indicate that mutations in PGM1 by exome sequencing cause hypoglycemia and liver abnormalities.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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