NOS1AP, Polyclonal Antibody

Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; C-terminal PDZ ligand of neuronal nitric oxide synthase protein; Nitric oxide synthase 1 adaptor protein; NOS1AP; CAPON; KIAA0464

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>95%, Protein G purified

Liquid

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-NOS1AP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity).

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

IHC: 1:20-1:200
IF: 1:50-1:200

Immunohistochemistry of paraffin-embedded human liver tissue using MBS7052189 at dilution of 1:100

Immunohistochemistry of paraffin-embedded human brain tissue using MBS7052189 at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using MBS7052189 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

55,569 Da

nitric oxide synthase 1 adaptor protein

carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

CAPON; KIAA0464  [Similar Products]

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]

NOS1AP: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: caveola; cytosol; mitochondrion; nuclear membrane; nucleus; perinuclear region of cytoplasm; sarcolemma; sarcoplasmic reticulum membrane; T-tubule; Z disc

Molecular Function: nitric-oxide synthase binding; protein binding

Biological Process: chemical signal regulation of heart rate; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity

Disease: Qt Interval, Variation In

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